Mariners vs. Astros Prediction, Odds, Picks - May 22

Julio Rodriguez and the Seattle Mariners square off against the Houston Astros and starter Lance McCullers on Thursday at 8:10 p.m. ET at Daikin Park. The Mariners are favored in this one, at -138, while the underdog Astros have +117 odds to win. Seattle (-1.5) is favored on the run line. The game's total is set at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Mariners-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best moments between the Houston Astros and the Tampa Bay Rays.

Mariners vs. Astros Game Information & Odds

• When: Thursday, May 22, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and ROOT Sports NW

Mariners vs. Astros Prediction

• Score Prediction: Astros 6, Mariners 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Mariners 52%, Astros 48%

Mariners vs. Astros Betting Insights

• This season, the Mariners have won 17 out of the 29 games, or 58.6%, in which they've been favored.
• This season Seattle has won 12 of its 20 games, or 60%, when favored by at least -138 on the moneyline.
• The sportsbooks' moneyline implies a 58% chance of a victory for the Mariners.
• The Astros have been victorious in seven, or 43.8%, of the 16 contests they have been chosen as underdogs in this season.
• Houston has a mark of 3-1 in contests where bookmakers favor it by +117 or worse on the moneyline.
• The Astros have an implied victory probability of 46.1% according to the moneyline set for this matchup.

Mariners Recent Betting Performance

• The Mariners have a 2-2 record over the four games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all had set totals), the Mariners combined with their opponents to go over the total three times.
• The Mariners' ATS record is 6-4-0 over their past 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh paces the Mariners in home runs (16) and runs batted in (33).
• Among all MLB batters, Raleigh is 90th in batting average, 34th in on-base percentage, and fifth in slugging.
• Raleigh has collected a hit in two games in a row. In his last five games he is batting .235 with two doubles, two home runs, four walks and three RBIs.
• Julio Rodriguez is hitting .231 with five doubles, two triples, nine home runs and 18 walks.
• Rodriguez is 35th in home runs in baseball, and 39th in RBI.
• Jorge Polanco is hitting .298 with six doubles, 10 home runs and nine walks.
• J.P. Crawford is hitting .269 to pace his team.

Mariners Team Props

Astros Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Astros have a record of 2-3.
• In their last 10 games with a total, the Astros and their opponents have combined to hit the over three times.
• The Astros have won four of their last 10 games against the spread.

Astros Recent Stats

Astros Player Insights

• Isaac Paredes paces the Astros in home runs (10) and runs batted in (28).
• Paredes' home run total places him 20th in the big leagues, and he ranks 39th in RBI.
• Paredes takes a hitting streak of six games into this game. In his last 10 outings he is hitting .289 with six home runs, five walks and 11 RBIs.
• Jeremy Pena is batting .297 with eight doubles, six home runs and 13 walks.
• Pena is 87th among all hitters in the big leagues in homers, and 82nd in RBI.
• Jake Meyers paces the Astros' lineup with a .306 batting average.
• Jose Altuve is batting .238 with six doubles, four home runs and 15 walks.

Astros Team Props

Astros vs. Rays Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Tampa Bay Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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