Guardians vs. Twins Prediction, Odds, Picks - April 28

Jose Ramirez and the Cleveland Guardians take the field on Monday at Progressive Field against Bailey Ober, who is starting for the Minnesota Twins. First pitch is set for 6:10 p.m. ET. The favored Guardians have -125 moneyline odds to win against the underdog Twins, who are listed at +106. Cleveland is the run-line favorite (-1.5). The over/under is 8 runs for the matchup (with -115 odds to go over and -105 odds on the under).

Here's everything you need from a betting perspective on the Guardians-Twins game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Twins Game Information & Odds

• When: Monday, April 28, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and MNNT

Guardians vs. Twins Prediction

• Score Prediction: Guardians 5, Twins 4
• Total Prediction: Over 8 runs
• Win Probabilities: Guardians 51%, Twins 49%

Guardians vs. Twins Betting Insights

• This season, the Guardians have won eight out of the 10 games in which they've been favored.
• This season Cleveland has won six of its seven games when favored by at least -125 on the moneyline.
• The bookmakers' moneyline implies a 55.6% chance of a victory for the Guardians.
• The Twins have come away with one win in the seven contests they have been listed as the underdogs in this season.
• Minnesota has been listed as an underdog of +106 or more on two occasions this season and lost both games.
• The Twins have an implied victory probability of 48.5% according to the moneyline set by oddsmakers for this matchup.

Guardians Recent Betting Performance

• In the last 10 games, the Guardians were listed as the moneyline favorite by bookmakers just two times, and they won both games.
• In their last 10 outings -- all had a set run total -- the Guardians and their opponents combined to go over the total six times.
• The Guardians' record against the spread is 5-5-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan paces the Guardians with a .346 batting average.
• In all of MLB, Kwan ranks 57th in homers and 46th in RBI.
• Kwan has collected a hit in 10 straight games. During his last 10 outings he is hitting .400 with four doubles, a home run, three walks and four RBI.
• Ramirez is hitting .263 with four doubles, five home runs and nine walks.
• Ramirez is 36th in home runs and 61st in RBI among all MLB batters this season.
• Kyle Manzardo paces the Guardians in home runs (seven) and runs batted in (18).
• Gabriel Arias is hitting .272 with five doubles, four home runs and five walks.
• Arias has recorded at least one hit in three games in a row. In his last five games he is batting .250 with two doubles and an RBI.

Guardians Team Props

Twins Recent Betting Performance

• The Twins have played as underdogs in three of their past 10 games and lost each of those contests.
• When it comes to hitting the over, the Twins and their opponents are 3-6-1 in their last 10 games with a total.
• The Twins have six wins against the spread in their last 10 chances.

Twins Recent Stats

Twins Player Insights

• Byron Keiron Buxton paces the Twins with six home runs and 15 runs batted in, while recording a team-high batting average of .237.
• Among all hitters in the majors, Buxton is 24th in home runs and 46th in RBI.
• Trevor Larnach is batting .234 with two doubles, four home runs and 13 walks.
• Larnach ranks 57th among all batters in MLB in homers, and 61st in RBI.
• Ty France paces the Twins in runs batted in (15) and has racked up a team-best batting average of .237.
• Carlos Javier Correa has seven doubles, a home run and seven walks while batting .211.

Twins Team Props

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Cleveland Guardians

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