Guardians vs. Royals Prediction, Odds, Picks - September 10

Steven Kwan and the Cleveland Guardians will hit the field at Progressive Field against the Kansas City Royals and Bobby Witt Jr. on Wednesday. The favored Guardians have -111 moneyline odds to win against the underdog Royals, who are listed at -108. Kansas City is the run-line favorite (-1.5). The total is 8 runs for this matchup.

Take a look at everything you need to know from a betting perspective on the Guardians-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Royals vs. Guardians Highlights | MLB on FOX

Check out the best moments between Kansas City Royals and the Cleveland Guardians.

Guardians vs. Royals Game Information & Odds

• When: Wednesday, September 10, 2025 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and FDSKC

Guardians vs. Royals Prediction

• Score Prediction: Guardians 5, Royals 4
• Total Prediction: Over 8 runs
• Win Probabilities: Guardians 52%, Royals 48%

Guardians vs. Royals Betting Insights

• The Guardians have been favorites in 59 games this season and won 36 (61%) of those contests.
• This season Cleveland has won 36 of its 57 games, or 63.2%, when favored by at least -111 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 52.6%.
• The Royals have come away with 37 wins in the 81 contests they have been listed as the underdogs in this season.
• This year, Kansas City has won 36 of 79 games when listed as at least -108 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Royals have a 51.9% chance of pulling out a win.

Guardians Recent Betting Performance

• In the last 10 games, the Guardians were listed as the moneyline favorite by oddsmakers just twice, and they won both games.
• Over their last 10 matchups (all had set totals), the Guardians combined with their opponents to go over the total four times.
• The Guardians are 6-4-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Not only does Jose Ramirez lead the Guardians in hitting with his .287 average, he also is their premier power option with 28 home runs and 76 RBI.
• In all of MLB, Ramirez ranks 21st in home runs and 45th in RBI.
• Ramirez carries a six-game hitting streak into this matchup. During his last 10 outings he is hitting .308 with three doubles, a triple, two home runs, two walks and eight RBIs.
• Steven Kwan is batting .275 with 25 doubles, a triple, 10 home runs and 50 walks.
• Kwan ranks 186th in homers and 161st in RBI among all hitters in the majors.
• Kyle Manzardo is batting .239 with 15 doubles, two triples, 25 home runs and 45 walks.
• Manzardo has at least one base hit in two straight games. In his last five games he is hitting .375 with a double, a home run, four walks and four RBIs.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 17 walks while hitting .227.

Guardians Team Props

Royals Recent Betting Performance

• In five games over the last 10 matchups when set as underdogs by bookmakers, the Royals had a record of 2-3.
• The Royals and their opponents have combined to hit the over two times in their last 10 games with a total.
• The Royals have two wins against the spread in their last 10 chances.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. leads the team in batting average with a mark of .293.
• Among all batters in MLB, Witt's home run total ranks 60th and his RBI tally is 41st.
• Maikel Garcia has 35 doubles, five triples, 16 home runs and 54 walks while batting .290.
• Garcia is currently 109th in homers and 71st in RBI in the big leagues.
• Vinnie Pasquantino leads the Royals in home runs (29) and runs batted in (99).
• Salvador Perez is hitting .235 with 33 doubles, 25 home runs and 23 walks.

Royals Team Props

Royals vs. Guardians Highlights | MLB on FOX

Check out the best moments between Kansas City Royals and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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