Guardians vs. Rays Prediction, Odds, Picks - August 25

The Cleveland Guardians and Tampa Bay Rays will meet on Monday at Progressive Field, at 6:40 p.m. ET, with Jose Ramirez and Junior Caminero -- two hot hitters -- expected to deliver at the plate. The favored Guardians have -120 moneyline odds against the underdog Rays, who are listed at +100. Cleveland is the run-line favorite (-1.5). The total for the matchup has been listed at 7.5 runs.

Here's everything you need to know from a betting perspective on the Guardians-Rays game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Rangers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Texas Rangers.

Guardians vs. Rays Game Information & Odds

• When: Monday, August 25, 2025 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: Fox Sports 1, CLEG, and FDSSUN

Guardians vs. Rays Prediction

• Score Prediction: Guardians 5, Rays 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Guardians 51%, Rays 49%

Guardians vs. Rays Betting Insights

• The Guardians have been favorites in 55 games this season and won 33 (60%) of those contests.
• Cleveland has a record of 28-16 in games when sportsbooks favor them by at least -120 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 54.5%.
• The Rays have been victorious in 26, or 39.4%, of the 66 contests they have been chosen as underdogs in this season.
• This season, Tampa Bay has been victorious 20 times in 45 chances when named as an underdog of at least +100 or longer on the moneyline.
• The moneyline set for this matchup implies the Rays have a 50% chance of walking away with the win.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite for three of their last 10 games, and finished 1-2 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Guardians and their opponents combined to go over the run total four times.
• The Guardians have a 4-6-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the Guardians with 26 home runs and 68 runs batted in, while racking up a team-high batting average of .288.
• Ramirez's home runs rank him 18th in MLB, and he is 48th in RBI.
• Steven Kwan is hitting .273 with 22 doubles, a triple, 10 home runs and 43 walks.
• Kwan is 172nd in homers and 183rd in RBI in the major leagues.
• Carlos Santana is batting .226 with 10 doubles, 11 home runs and 52 walks.
• Santana will look to build on his three-game hitting in this game. In his last five games he is hitting .176 with a double, three walks and an RBI.
• Kyle Manzardo is batting .233 with 14 doubles, two triples, 21 home runs and 40 walks.
• Manzardo brings a three-game streak with at least one hit into this one. During his last five outings he is hitting .176 with .

Guardians Team Props

Rays Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Rays have a record of 1-4.
• In their last 10 games with a total, the Rays and their opponents are 7-2-1 when it comes to hitting the over.
• The Rays have a record of 4-6-0 ATS over their last 10 games.

Rays Recent Stats

Rays Player Insights

• Caminero leads the Rays in home runs (37) and runs batted in (91).
• Caminero's home run total puts him sixth in MLB, and he is ninth in RBI.
• Caminero carries a four-game hitting streak into this matchup. In his last five games he is batting .200 with two home runs, three walks and six RBIs.
• Yandy Diaz has 22 doubles, a triple, 21 home runs and 40 walks while batting .279.
• Diaz ranks 43rd overall in home runs and 32nd in RBI this year.
• Brandon Lowe has 13 doubles, 25 home runs and 31 walks while hitting .266.
• Chandler Simpson is batting .307 with 11 doubles, three triples and 18 walks.

Rays Team Props

Guardians vs. Rangers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Texas Rangers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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