Giants vs. Padres Prediction, Odds, Picks - June 4

Kyle Harrison will start for the San Francisco Giants on Wednesday at Oracle Park against Manny Machado and the San Diego Padres. First pitch is at 9:45 p.m. ET for the third game of a four-game series. The Padres are +104 moneyline underdogs in this matchup against the favored Giants (-124). San Francisco is the favorite on the run line (-1.5 with +170 odds). The over/under is 7.5 runs for the game (with +105 odds to hit the over and -125 odds to go under).

Here is everything you need to know from a betting perspective on the Giants-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Padres Game Information & Odds

• When: Wednesday, June 4, 2025 at 9:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and SDPA

Giants vs. Padres Prediction

• Score Prediction: Giants 3, Padres 2
• Total Prediction: Under 7.5 runs
• Win Probabilities: Giants 57%, Padres 43%

Giants vs. Padres Betting Insights

• The Giants have won 22, or 57.9%, of the 38 games they've played as favorites this season.
• San Francisco has a record of 18-12, a 60% win rate, when favored by -124 or more by oddsmakers this season.
• The implied probability of a win from the Giants, based on the moneyline, is 55.4%.
• The Padres have won in 14, or 56%, of the 25 contests they have been named as odds-on underdogs this year.
• This year, San Diego has won nine of 18 games when listed as at least +104 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Padres have a 49% chance of pulling out a win.

Giants Recent Betting Performance

• The Giants were the moneyline favorite in eight of their last 10 games, and they finished 3-5 in those matchups.
• Over their last 10 matchups, the Giants have not combined with their opponents to go over the run total (all 10 had set totals).
• The Giants are 2-8-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee is hitting .269 with 14 doubles, two triples, six home runs and 15 walks.
• Among all hitters in MLB, Lee's home run total places him 115th, and his RBI tally ranks him 57th.
• Heliot Ramos has hit 11 home runs while hitting .293. Both are team-highs.
• Of all major league batters, Ramos is 31st in homers and 57th in RBI.
• Ramos has seven games in a row with at least one hit. During his last 10 games he is batting .279 with a triple, two home runs, three walks and five RBIs.
• Wilmer Flores leads the Giants with 47 runs batted in.
• Flores will look to build on his three-game hitting in this matchup. In his last five games he is hitting .211 with two RBIs.
• Matt Chapman is batting .236 with 10 doubles, 10 home runs and 39 walks.
• Chapman takes a two-game streak with at least one hit into this one. During his last five outings he is hitting .375 with a double, a home run, four walks and an RBI.

Giants Team Props

Padres Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Padres have a record of 3-1.
• In their last 10 games with a total, the Padres and their opponents have failed to hit the over seven times.
• The Padres have won five of their last 10 games against the spread.

Padres Recent Stats

Padres Player Insights

• Machado leads the Padres with a .315 batting average.
• Among all batters in the majors, Machado's home run total ranks 92nd and his RBI tally ranks 73rd.
• Fernando Tatis Jr. has hit a team-best 13 home runs.
• Tatis is currently 15th in homers and 79th in RBI in the major leagues.
• Luis Arraez is hitting .283 with 12 doubles, three triples, three home runs and 11 walks.
• Gavin Sheets has sent home a team-leading 34 runs batted in.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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