Giants vs. Brewers Prediction, Odds, Picks - April 22

Brice Turang and the Milwaukee Brewers will hit the field against the San Francisco Giants and starter Jordan Hicks on Tuesday. First pitch is at 9:45 p.m. ET at Oracle Park. The Giants are -147 moneyline favorites for this matchup with the Brewers (+123). San Francisco is the favorite on the run line (-1.5 with +146 odds). The over/under is 8 runs for the matchup (with -110 odds to hit the over and -110 odds to go under).

Here's everything you need to know from a betting perspective on the Giants-Brewers game, regarding the run line, moneyline and total, plus expert picks.

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Athletics vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Athletics and the Milwaukee Brewers.

Giants vs. Brewers Game Information & Odds

• When: Tuesday, April 22, 2025 at 9:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and FDSWIX

Giants vs. Brewers Prediction

• Score Prediction: Giants 5, Brewers 4
• Total Prediction: Over 8 runs
• Win Probabilities: Giants 57%, Brewers 43%

Giants vs. Brewers Betting Insights

• The Giants have been favorites in 11 games this season and won eight (72.7%) of those contests.
• San Francisco has entered three games this season favored by -147 or more and is 1-2 in those contests.
• The oddsmakers' moneyline implies a 59.5% chance of a victory for the Giants.
• The Brewers have won in two of the nine contests they have been named as odds-on underdogs this year.
• Milwaukee has a win-loss record of 1-3 when favored by +123 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Brewers have a 44.8% chance of coming away with a victory in the contest.

Giants Recent Betting Performance

• The Giants played as the moneyline favorite in three of their last 10 games, and went 2-1 in those matchups.
• Over their last 10 outings (all had set totals), the Giants combined with their opponents to go over the total six times.
• The Giants' record against the spread is 4-6-0 over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee paces the Giants with a team-best batting average of .329.
• Among all hitters in baseball, Lee's home run total places him 74th, and his RBI tally puts him 25th.
• Wilmer Flores has hit seven home runs with 24 RBI. Both pace his team.
• Including all major league hitters, Flores is fifth in home runs and second in RBI.
• Matt James Chapman is batting .231 with three doubles, four home runs and 22 walks.
• Mike Yastrzemski has six doubles, three home runs and 14 walks while hitting .286.
• Yastrzemski has recorded at least one hit in two games in a row. In his last five games he is hitting .250 with two doubles, four walks and two RBI.

Giants Team Props

Brewers Recent Betting Performance

• The Brewers have played as underdogs in six of their past 10 games and have gone 2-4 in those contests.
• In their last 10 games with a total, the Brewers and their opponents have combined to hit the over two times.
• The Brewers have six wins against the spread in their last 10 chances.

Brewers Recent Stats

Brewers Player Insights

• Jackson Chourio leads the Brewers with five long balls and runs batted in, driving in 19.
• Chourio's home run total puts him 25th in MLB, and he ranks seventh in RBI.
• Turang has a double, three home runs and five walks while batting .308.
• Among all MLB hitters, Turang is 74th in home runs and 72nd in RBI.
• Sal Frelick paces the Brewers' lineup with a .338 batting average.
• William Jesus (Castillo) Contreras is batting .247 with two doubles, three home runs and 14 walks.

Brewers Team Props

Athletics vs. Brewers Highlights | MLB on FOX

Check out the best moments between the Athletics and the Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco Giants

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