Dodgers vs. Guardians Prediction, Odds, Picks - May 27

Shohei Ohtani and the Los Angeles Dodgers will take the field against the Cleveland Guardians and Carlos Santana at Progressive Field on Tuesday at 6:10 p.m. ET. The Dodgers are -129 moneyline favorites in this matchup against the Guardians (+110). Los Angeles (-1.5) is the favorite on the run line. The game's total has been set at 9 runs.

Here's everything you need from a betting perspective on the Dodgers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Dodgers vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Los Angeles Dodgers and the Cleveland Guardians.

Dodgers vs. Guardians Game Information & Odds

• When: Tuesday, May 27, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and SportsNet LA

Dodgers vs. Guardians Prediction

• Score Prediction: Dodgers 5, Guardians 4
• Total Prediction: Under 9 runs
• Win Probabilities: Dodgers 51%, Guardians 49%

Dodgers vs. Guardians Betting Insights

• The Dodgers have been favorites in 45 games this season and won 29 (64.4%) of those contests.
• This season Los Angeles has won 27 of its 42 games, or 64.3%, when favored by at least -129 on the moneyline.
• The Dodgers have a 56.3% chance to win this game based on the implied probability of the moneyline.
• The Guardians have won in 16, or 50%, of the 32 contests they have been named as odds-on underdogs this year.
• Cleveland has a mark of 5-11 in contests where sportsbooks favor it by +110 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 47.6% chance of pulling out a win.

Dodgers Recent Betting Performance

• The Dodgers went 3-4 across the seven games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all had set totals), the Dodgers combined with their opponents to go over the total five times.
• The Dodgers have put together a 3-7-0 record against the spread over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Ohtani has left the yard 19 times this season, the highest mark on the Dodgers, while hitting .295 with 33 RBI.
• In all of MLB, Ohtani is first in homers and 23rd in RBI.
• Ohtani brings a hitting streak of two games into this matchup. During his last five outings he is hitting .150 with two home runs, three walks and two RBIs.
• Mookie Betts is batting .258 with five doubles, a triple, eight home runs and 24 walks.
• Betts is 54th in home runs in the majors, and 27th in RBI.
• Betts has three straight games with at least one hit. In his last five games he is hitting .227 with a walk and an RBI.
• Freddie Freeman has put up a team-high batting average of .361.
• Freeman will look to build on his two-game hitting in this game. In his last five games he is batting .278 with a double, four walks and an RBI.
• Teoscar Hernandez has been productive as he paces his team with 42 RBI.
• Hernandez has recorded at least one hit in five straight games. During his last five outings he is batting .286 with three doubles, a home run and seven RBIs.

Dodgers Team Props

Guardians Recent Betting Performance

• In seven games over the last 10 matchups when set as underdogs by oddsmakers, the Guardians had a record of 4-3.
• The Guardians and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Guardians are 4-6-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez has 12 doubles, a triple, nine home runs and 17 walks while hitting .313.
• Ramirez is 40th in homers and 73rd in RBI among all hitters in the big leagues.
• Ramirez carries a 19-game hitting streak into this matchup. During his last 10 outings he is batting .372 with four doubles, a triple, a home run, a walk and four RBIs.
• Steven Kwan is hitting .314 to lead the lineup.
• Kwan is currently 154th in home runs and 135th in RBI in the major leagues.
• Santana has five doubles, six home runs and 27 walks while hitting .235.
• Kyle Manzardo paces the Guardians with 10 long balls and runs batted in, driving in 28.

Guardians Team Props

Dodgers vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Los Angeles Dodgers and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

Los Angeles Dodgers