Diamondbacks vs. Reds Prediction, Odds, Picks - August 22

Noelvi Marte and the Cincinnati Reds take the field against Corbin Carroll and the Arizona Diamondbacks at Chase Field on Friday at 9:40 p.m. ET. The Diamondbacks are favored in this one, at -132, while the underdog Reds have +112 odds to win. Arizona is favored on the run line (-1.5). The matchup's over/under has been set at 9 runs.

Here's everything you need from a betting perspective on the Diamondbacks-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Reds Game Information & Odds

• When: Friday, August 22, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and FDSOH

Diamondbacks vs. Reds Prediction

• Score Prediction: Diamondbacks 5, Reds 4
• Total Prediction: Over 9 runs
• Win Probabilities: Diamondbacks 51%, Reds 49%

Diamondbacks vs. Reds Betting Insights

• The Diamondbacks have been favorites in 78 games this season and won 40 (51.3%) of those contests.
• Arizona is 25-24 this season when entering a game favored by -132 or more on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Diamondbacks have a 56.9% chance to win.
• The Reds have won in 35, or 51.5%, of the 68 contests they have been named as odds-on underdogs this year.
• This season, Cincinnati has been victorious 15 times in 38 chances when named as an underdog of at least +112 or worse on the moneyline.
• The Reds have an implied victory probability of 47.2% according to the moneyline set by oddsmakers for this matchup.

Diamondbacks Recent Betting Performance

• The Diamondbacks have a 3-4 record from the seven games they were moneyline favorites over their last 10 matchups.
• In their last 10 matchups (all had set totals), the Diamondbacks combined with their opponents to go over the total four times.
• The Diamondbacks have put together a 6-4-0 record against the spread over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo is the Diamondbacks RBI leader this season, driving in 81 runs to go with his 13 home runs and .287 batting average.
• In all of the majors, Perdomo is 118th in home runs and 16th in RBI.
• Carroll has shown his power as he paces his team with 27 home runs.
• Carroll is 13th in homers and 52nd in RBI among all major league hitters this year.
• Carroll has eight games in a row with at least one hit. During his last 10 games he is hitting .293 with a double, two triples, two home runs, five walks and five RBIs.
• Ketel Marte has put up a team-best batting average of .293.
• Lourdes Gurriel Jr. has 23 doubles, two triples, 17 home runs and 29 walks while batting .249.
• Gurriel brings a seven-game streak with at least one hit into this one. In his last 10 outings he is batting .250 with a double, three home runs, three walks and 12 RBIs.

Diamondbacks Team Props

Reds Recent Betting Performance

• The Reds have played as underdogs in six of their past 10 games and have gone 3-3 in those contests.
• When it comes to hitting the over, the Reds and their opponents are 4-6-0 in their last 10 games with a total.
• The Reds are 7-3-0 ATS over their last 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz leads the Reds with 19 long balls and runs batted in, driving in 76.
• De La Cruz is 55th in home runs and 21st in RBI among all hitters in MLB.
• TJ Friedl is batting .267 with 18 doubles, two triples, 10 home runs and 60 walks.
• Friedl ranks 160th in homers and 176th in RBI among all MLB batters this year.
• Spencer Steer is batting .238 with 17 doubles, two triples, 15 home runs and 38 walks.
• Gavin Lux leads the team in batting average with a mark of .277.

Reds Team Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

Cincinnati Reds