Diamondbacks vs. Guardians Prediction, Odds, Picks - August 20

Parker Messick starts for the Cleveland Guardians against Corbin Carroll and the Arizona Diamondbacks on Wednesday at 3:40 p.m. ET. The favored Diamondbacks have -120 moneyline odds against the underdog Guardians, who are listed at +100. Cleveland is the favorite on the run line (-1.5 with +160 odds). The contest's over/under has been listed at 8.5 runs.

Take a look at everything you need from a betting perspective on the Diamondbacks-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Guardians Game Information & Odds

• When: Wednesday, August 20, 2025 at 3:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and CLEG

Diamondbacks vs. Guardians Prediction

• Score Prediction: Diamondbacks 6, Guardians 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Diamondbacks 52%, Guardians 48%

Diamondbacks vs. Guardians Betting Insights

• This season, the Diamondbacks have won 39 out of the 77 games, or 50.6%, in which they've been favored.
• Arizona has a record of 29-31 in games when bookmakers favor them by at least -120 on the moneyline.
• The implied probability of a win from the Diamondbacks, based on the moneyline, is 54.5%.
• The Guardians have been chosen as underdogs in 67 games this year and have walked away with the win 30 times (44.8%) in those games.
• Cleveland has a mark of 23-29 in contests where bookmakers favor it by +100 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 50% chance of walking away with the win.

Diamondbacks Recent Betting Performance

• The Diamondbacks were the moneyline favorite in seven of their last 10 games, and finished 3-4 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Diamondbacks and their opponents combined to hit the over five times.
• The Diamondbacks' ATS record is 6-4-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo has been the Diamondbacks top run producer this season, leading the team with 81 RBI while hitting .289 with 13 home runs.
• Including all MLB hitters, Perdomo is 21st in batting average, seventh in on-base percentage, and 71st in slugging.
• Perdomo has collected a hit in four straight games. During his last five outings he is hitting .316 with a triple, four walks and two RBIs.
• Corbin Carroll's 27 home runs pace his team.
• Carroll ranks 12th in homers and 51st in RBI on the season.
• Carroll carries a seven-game streak with at least one hit into this contest. During his last 10 outings he is batting .310 with two doubles, two triples, two home runs, five walks and six RBIs.
• Ketel Marte leads the Diamondbacks with a .293 batting average.
• Lourdes Gurriel Jr. is batting .247 with 23 doubles, two triples, 16 home runs and 29 walks.
• Gurriel is riding a six-game hitting streak into this one. During his last 10 outings he is hitting .222 with a double, two home runs, three walks and 10 RBIs.

Diamondbacks Team Props

Guardians Recent Betting Performance

• The Guardians have been underdogs twice in the last 10 games and split those matchups 1-1.
• In their last 10 games with a total, the Guardians and their opponents have combined to hit the over five times.
• The Guardians are 4-6-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the lineup with a batting average of .291, and paces the Guardians in home runs, with 26 and runs batted in with 66.
• Among all hitters in MLB, Ramirez is 16th in home runs and 49th in RBI.
• Steven Kwan is batting .278 with 22 doubles, a triple, 10 home runs and 43 walks.
• Kwan ranks 159th overall in homers and 174th in RBI this season.
• Carlos Santana is batting .226 with nine doubles, 11 home runs and 52 walks.
• Kyle Manzardo has 14 doubles, two triples, 21 home runs and 40 walks while batting .235.

Guardians Team Props

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Check out the best moments between the Arizona Diamondbacks and Colorado Rockies.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

Cleveland Guardians