Diamondbacks vs. Astros Prediction, Odds, Picks - July 22

Eugenio Suarez and the Arizona Diamondbacks will try to defeat Jose Altuve and the Houston Astros at Chase Field on Tuesday at 9:40 p.m. ET. The Diamondbacks are the favorite in this one, at -116, while the underdog Astros have -102 odds to play spoiler. Houston is favored on the run line (-1.5 with +168 odds). An 8.5-run over/under has been set in the contest.

Here's everything you need to know from a betting perspective on the Diamondbacks-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Astros Game Information & Odds

• When: Tuesday, July 22, 2025 at 9:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: ARID and SCHN

Diamondbacks vs. Astros Prediction

• Score Prediction: Diamondbacks 6, Astros 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Diamondbacks 50%, Astros 50%

Diamondbacks vs. Astros Betting Insights

• This season, the Diamondbacks have won 33 out of the 65 games, or 50.8%, in which they've been favored.
• Arizona is 28-28 this season when entering a game favored by -116 or more on the moneyline.
• The moneyline for this contest implies a 53.7% chance of a victory for the Diamondbacks.
• The Astros have won in 19, or 59.4%, of the 32 contests they have been named as odds-on underdogs this year.
• Houston has a win-loss record of 15-11 when favored by -102 or worse by sportsbooks this year.
• The Astros have an implied victory probability of 50.5% according to the moneyline set for this matchup.

Diamondbacks Recent Betting Performance

• The Diamondbacks went 2-2 across the four games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups, the Diamondbacks and their opponents combined to go over the run total five times (all 10 of the games had set totals).
• The Diamondbacks' record against the spread is 6-4-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo is hitting .270 with 20 doubles, two triples, 10 home runs and 59 walks.
• Perdomo's home runs rank him 131st in the majors, and he ranks ninth in RBI.
• Suarez has hit 36 home runs with 86 runs batted in. Both pace his team.
• Suarez ranks second in home runs and first in RBI on the season.
• Suarez has six straight games with at least one hit. During his last 10 games he is batting .306 with a double, eight home runs, five walks and 12 RBIs.
• Josh Naylor leads the Diamondbacks with a .293 batting average.
• Naylor is on a two-game hitting streak entering this contest. During his last five outings he is hitting .263 with a double and two walks.
• Corbin Carroll is batting .250 with 16 doubles, 13 triples, 21 home runs and 32 walks.
• Carroll has recorded at least one hit in three straight games. During his last five outings he is hitting .261 with a double, three triples, a walk and two RBIs.

Diamondbacks Team Props

Astros Recent Betting Performance

• The Astros have played as underdogs in four of their past 10 games and won two of those contests.
• The Astros and their opponents have combined to hit the over six times in their last 10 games with a total.
• The Astros have four wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Altuve has driven in the most runs for the Astros with 53 runs batted in.
• Among all batters in MLB, Altuve ranks 39th in homers and 51st in RBI.
• Altuve takes a hitting streak of three games into this matchup. In his last five games he is hitting .333 with three doubles, two walks and an RBI.
• Yainer Diaz is hitting .239 with 11 doubles, a triple, 13 home runs and 14 walks.
• Among all MLB hitters, Diaz is 77th in home runs and 115th in RBI.
• Christian Walker is batting .230 with 13 doubles, a triple, 13 home runs and 25 walks.
• Cam Smith is batting .269 with 17 doubles, two triples, seven home runs and 27 walks.

Astros Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Diamondbacks

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