Cubs vs. White Sox Prediction, Odds, Picks - July 27

Kyle Tucker and the Chicago Cubs take on Miguel Vargas and the Chicago White Sox on Sunday at 2:10 p.m. ET. The White Sox are +139 moneyline underdogs for this matchup with the favorite Cubs (-166). The Cubs are favored on the run line (-1.5). An 8.5-run over/under has been set for the game.

Here's everything you need from a betting perspective on the Cubs-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best highlights between the Chicago White Sox and Chicago Cubs.

Cubs vs. White Sox Game Information & Odds

• When: Sunday, July 27, 2025 at 2:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and MARQ

Cubs vs. White Sox Prediction

• Score Prediction: Cubs 3, White Sox 2
• Total Prediction: Under 8.5 runs
• Win Probabilities: Cubs 54%, White Sox 46%

Cubs vs. White Sox Betting Insights

• The Cubs have entered the game as favorites 72 times this season and won 49, or 68.1%, of those games.
• This season, the Cubs have won 17 of their 24 games, or 70.8%, when favored by at least -166 on the moneyline.
• The moneyline for this contest implies a 62.4% chance of a victory for the Cubs.
• The White Sox have come away with 37 wins in the 103 contests they have been listed as the underdogs in this season.
• This season, the White Sox have come away with a win 19 times in 64 chances when named as an underdog of at least +139 or worse on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 41.8% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs have a 4-3 record over the seven games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all 10 of them had set totals), the Cubs and their opponents combined to go over the run total four times.
• The Cubs' record against the spread is 6-4-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Tucker is hitting .274 with 19 doubles, four triples, 18 home runs and 66 walks.
• Tucker ranks 36th in home runs and 41st in RBI among all hitters in baseball.
• Tucker carries a two-game hitting streak into this matchup. During his last five outings he is batting .118 with five walks and an RBI.
• Pete Crow-Armstrong has hit 27 home runs to lead his team.
• Crow-Armstrong is sixth in home runs and ninth in RBI in the majors.
• Seiya Suzuki has racked up a team-high 81 runs batted in.
• Nico Hoerner has a club-high .286 batting average.
• Hoerner is riding a four-game hitting streak into this one. During his last five outings he is hitting .250 with a walk and an RBI.

Cubs Team Props

White Sox Recent Betting Performance

• In 10 games over the last 10 matchups when set as underdogs by sportsbooks, the White Sox had a record of 6-4.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over four times.
• The White Sox have eight wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Vargas has posted a team-high 12 home runs and has driven in 41 runs.
• Vargas' home run total puts him 101st in the big leagues, and he ranks 113th in RBI.
• Andrew Benintendi has 12 doubles, two triples, 11 home runs and 27 walks while hitting .235.
• Benintendi is currently 113th in homers and 136th in RBI in the major leagues.
• Chase Meidroth has 11 doubles, three home runs and 33 walks while batting .257.
• Luis Robert has driven in a team-high 41 runs batted in.

White Sox Team Props

Cubs vs. White Sox Highlights | MLB on FOX

Check out the best highlights between the Chicago White Sox and Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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