Cubs vs. Pirates Prediction, Odds, Picks - September 17

Pete Crow-Armstrong and the Chicago Cubs will play Bryan Reynolds and the Pittsburgh Pirates on Wednesday at PNC Park, at 12:35 p.m. ET. The Pirates are +120 moneyline underdogs in this matchup against the favored Cubs (-143). Chicago is a 1.5-run favorite (at +118 odds). An 8-run total has been set in the game.

Here's everything you need from a betting perspective on the Cubs-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Rays vs. Cubs Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and Chicago Cubs.

Cubs vs. Pirates Game Information & Odds

• When: Wednesday, September 17, 2025 at 12:35 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: MLB Network, SportsNet PT, and MARQ

Cubs vs. Pirates Prediction

• Score Prediction: Cubs 5, Pirates 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cubs 52%, Pirates 48%

Cubs vs. Pirates Betting Insights

• The Cubs have won 69, or 63.3%, of the 109 games they've played as favorites this season.
• Chicago has a record of 46-23 in games when sportsbooks favor them by at least -143 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Cubs have a 58.8% chance to win.
• The Pirates have been victorious in 43, or 41%, of the 105 contests they have been chosen as underdogs in this season.
• Pittsburgh has a mark of 23-41 in contests where sportsbooks favor it by +120 or worse on the moneyline.
• The moneyline set for this matchup implies the Pirates have a 45.5% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs have a 4-3 record from the seven games they were favored on the moneyline over their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Cubs and their opponents combined to hit the over on the total three times.
• The Cubs have a 6-4-0 record against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner's .301 average leads the Cubs this year. His resume also includes six homers and driven in 59 RBI.
• Among all MLB hitters, Hoerner is eighth in batting average, 36th in on-base percentage, and 102nd in slugging.
• Hoerner carries an 11-game hitting streak into this matchup. In his last 10 outings he is batting .450 with four doubles, a triple, four walks and three RBIs.
• Crow-Armstrong has shown off his power as he paces his team with 29 home runs.
• Including all major league batters, Crow-Armstrong ranks 21st in home runs and 22nd in RBI.
• Crow-Armstrong enters this game looking for his third game in a row with a hit. During his last five outings he is hitting .150 with a double, a home run, a walk and three RBIs.
• Ian Happ has 28 doubles, 22 home runs and 84 walks while hitting .241.
• Seiya Suzuki's 91 runs batted in are a team-high mark.
• Suzuki takes a six-game streak with at least one hit into this one. In his last 10 games he is hitting .211 with a double, six walks and four RBIs.

Cubs Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in five of their past 10 games and lost each of those contests.
• When it comes to hitting the over, the Pirates and their opponents are 2-8-0 in their last 10 games with a total.
• The Pirates have a record of 3-7-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Reynolds leads the Pirates with 71 runs batted in while accumulating a team-best batting average of .241.
• Reynolds is 131st in homers and 71st in RBI among all hitters in the majors.
• Oneil Cruz has shown his power as he leads his team with 19 home runs.
• Among all major league hitters, Cruz ranks 81st in home runs and 126th in RBI.
• Andrew McCutchen is hitting .239 with 22 doubles, 13 home runs and 63 walks.
• Spencer Horwitz has 22 doubles, nine home runs and 38 walks while batting .260.

Pirates Team Props

Rays vs. Cubs Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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