Cubs vs. Pirates Prediction, Odds, Picks - September 15

Ian Happ and the Chicago Cubs will take the field against the Pittsburgh Pirates and Jared Triolo at PNC Park on Monday at 6:40 p.m. ET. Oddsmakers list the Cubs as -120 favorites on the moneyline, while giving the underdog Pirates +100 moneyline odds. Chicago is the run-line favorite (-1.5). An 8-run total is set for the contest.

Here's everything you need from a betting perspective on the Cubs-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Pirates Game Information & Odds

• When: Monday, September 15, 2025 at 6:40 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: MLB Network, SportsNet PT, and MARQ

Cubs vs. Pirates Prediction

• Score Prediction: Cubs 4, Pirates 3
• Total Prediction: Under 8 runs
• Win Probabilities: Cubs 52%, Pirates 48%

Cubs vs. Pirates Betting Insights

• This season, the Cubs have been favored 108 times and won 68, or 63%, of those games.
• Chicago has entered 96 games this season favored by -120 or more and is 64-32 in those contests.
• The moneyline for this contest implies a 54.5% chance of a victory for the Cubs.
• The Pirates have been underdogs in 104 games this season and have come away with the win 43 times (41.3%) in those contests.
• Pittsburgh has a mark of 37-56 in contests where bookmakers favor it by +100 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Pirates have a 50% chance of pulling out a win.

Cubs Recent Betting Performance

• The Cubs went 4-4 over the eight games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all had set totals), the Cubs combined with their opponents to go over the total four times.
• The Cubs are 5-5-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner's .299 average leads the Cubs this year. His resume also includes six homers and driven in 59 RBI.
• Including all MLB hitters, Hoerner ranks seventh in batting average, 39th in on-base percentage, and 102nd in slugging.
• Hoerner takes a hitting streak of nine games into this game. During his last 10 games he is hitting .410 with five doubles, a triple, a home run, four walks and five RBIs.
• Pete Crow-Armstrong's 28 home runs are a team-high mark.
• Crow-Armstrong is 24th in home runs in MLB, and 25th in RBI.
• Happ is batting .242 with 28 doubles, 22 home runs and 82 walks.
• Seiya Suzuki has made the most of his opportunities as he paces his team with 91 runs batted in.
• Suzuki has recorded at least one hit in six straight games. During his last 10 outings he is hitting .211 with a double, six walks and four RBIs.

Cubs Team Props

Pirates Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Pirates have a record of 1-5.
• When it comes to hitting the over, the Pirates and their opponents are 3-7-0 in their last 10 games with a total.
• The Pirates have a record of 4-6-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• The Pirates are led in runs batted in by Bryan Reynolds with a mark of 71, he also leads the team in hitting, posting an average of .242.
• Among all hitters in the majors, Reynolds' home run total is 128th and his RBI tally is 69th.
• Andrew McCutchen has 22 doubles, 13 home runs and 62 walks while hitting .241.
• McCutchen ranks 152nd overall in home runs and 129th in RBI this year.
• Oneil Cruz leads the Pirates with 19 long balls.
• Spencer Horwitz has 21 doubles, nine home runs and 37 walks while batting .260.

Pirates Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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