Cubs vs. Mets Prediction, Odds, Picks - September 24

The Chicago Cubs and Michael Busch will take on the New York Mets and Pete Alonso on Wednesday at 8:05 p.m. ET, in the second game of a three-game series at Wrigley Field. The Mets have been listed as -110 moneyline underdogs for this matchup with the favored Cubs (-110). New York is a 1.5-run favorite (at +152 odds). The total is 7.5 runs for this game.

Check out everything you need to know from a betting perspective on the Cubs-Mets game, regarding the run line, moneyline and total, plus expert picks.

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Mets vs. Cubs Highlights | MLB on FOX

Enjoy the best moments between the New York Mets and the Chicago Cubs.

Cubs vs. Mets Game Information & Odds

• When: Wednesday, September 24, 2025 at 8:05 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: ESPN

Cubs vs. Mets Prediction

• Score Prediction: Cubs 5, Mets 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cubs 55%, Mets 45%

Cubs vs. Mets Betting Insights

• The Cubs have been favorites in 112 games this season and won 70 (62.5%) of those contests.
• Chicago is 70-42 this season when entering a game favored by -110 or more on the moneyline.
• The implied probability of a win from the Cubs, based on the moneyline, is 52.4%.
• The Mets have been chosen as underdogs in 46 games this year and have walked away with the win 19 times (41.3%) in those games.
• New York has a win-loss record of 19-27 when favored by -110 or worse by sportsbooks this year.
• The Mets have an implied victory probability of 52.4% according to the moneyline set by sportsbooks for this matchup.

Cubs Recent Betting Performance

• The Cubs have a 3-2 record from the five games they were moneyline favorites over their last 10 matchups.
• Over their last 10 matchups, the Cubs and their opponents combined to go over the total four times (all 10 games had set totals).
• The Cubs' ATS record is 6-4-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner leads the Cubs with a .302 batting average.
• In all of the majors, Hoerner ranks 278th in homers and 124th in RBI.
• Pete Crow-Armstrong is batting .246 with 37 doubles, four triples, 29 home runs and 29 walks.
• Crow-Armstrong is 30th in homers and 28th in RBI on the year.
• Ian Happ is batting .241 with 30 doubles, 23 home runs and 86 walks.
• Happ has at least one base hit in two straight games. During his last five outings he is hitting .190 with two doubles, a walk and three RBIs.
• Seiya Suzuki has put up 92 runs batted in to pace his team.
• Suzuki is riding a two-game hitting streak into this one. During his last five outings he is hitting .200 with a double, two walks and an RBI.

Cubs Team Props

Mets Recent Betting Performance

• Over the past 10 games, the Mets have been underdogs just once and won that contest.
• The Mets and their opponents have combined to hit the over five times in their last 10 games with a total.
• The Mets have a record of 5-5-0 ATS over their last 10 games.

Mets Recent Stats

Mets Player Insights

• Juan Soto has collected a team-best 42 home runs.
• Soto's home run total places him seventh in MLB, and he is 10th in RBI.
• Soto carries a seven-game hitting streak into this matchup. In his last 10 games he is hitting .308 with two doubles, three home runs, six walks and nine RBIs.
• Francisco Lindor is hitting .268 with 34 doubles, 29 home runs and 60 walks.
• Lindor ranks 30th among all hitters in MLB in homers, and 37th in RBI.
• Alonso has the top batting average on the Mets (.273) and paces in runs batted in (123).
• Brandon Nimmo is hitting .261 with 27 doubles, 25 home runs and 49 walks.

Mets Team Props

Mets vs. Cubs Highlights | MLB on FOX

Enjoy the best moments between the New York Mets and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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