Cubs vs. Giants Prediction, Odds, Picks - May 6

Pete Crow-Armstrong and the Chicago Cubs take on the San Francisco Giants and starter Justin Verlander on Tuesday at 7:40 p.m. ET at Wrigley Field. The Cubs are favored in this one, at -150, while the underdog Giants have +126 odds to upset. Chicago is the run-line favorite (-1.5). The game's total is set at 8 runs.

Here is everything you need from a betting perspective on the Cubs-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Cubs Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Chicago Cubs.

Cubs vs. Giants Game Information & Odds

• When: Tuesday, May 6, 2025 at 7:40 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and NBCS-BA

Cubs vs. Giants Prediction

• Score Prediction: Cubs 5, Giants 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cubs 57%, Giants 43%

Cubs vs. Giants Betting Insights

• The Cubs have won 14, or 70%, of the 20 games they've played as favorites this season.
• Chicago is 6-2 this season when entering a game favored by -150 or more on the moneyline.
• The moneyline for this contest implies a 60% chance of a victory for the Cubs.
• The Giants have been chosen as underdogs in 14 games this year and have walked away with the win seven times (50%) in those games.
• San Francisco has a mark of 1-3 in contests where bookmakers favor it by +126 or worse on the moneyline.
• The moneyline set for this matchup implies the Giants have a 44.2% chance of walking away with the win.

Cubs Recent Betting Performance

• The Cubs went 5-3 across the eight games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Cubs combined with their opponents to go over the total five times.
• The Cubs have put together a 6-4-0 record against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker has racked up a team-high nine home runs.
• Tucker's home runs put him seventh in MLB, and he is sixth in RBI.
• Pete Crow-Armstrong has hit nine home runs to lead his team.
• Crow-Armstrong is seventh in home runs and 13th in RBI among all batters in the majors.
• Crow-Armstrong enters this game looking for his fifth game in a row with a hit. During his last five outings he is batting .250 with three home runs and five RBIs.
• Ian Happ leads the Cubs with a .287 batting average.
• Happ has at least one base hit in seven straight games. During his last 10 games he is hitting .342 with four doubles, a home run, six walks and six RBIs.
• Carson Kelly is hitting .361 with two doubles, a triple, eight home runs and 17 walks.
• Kelly is riding a six-game hitting streak into this one. In his last 10 games he is hitting .324 with a double, four home runs, six walks and 10 RBIs.

Cubs Team Props

Giants Recent Betting Performance

• The Giants have been underdogs twice in the last 10 games and lost both contests.
• The Giants and their opponents have combined to hit the over five times in their last 10 games with a total.
• The Giants have a record of 3-7-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee leads the team in batting average with a mark of .303.
• Among all hitters in the majors, Lee is 130th in home runs and 38th in RBI.
• Matt Chapman has a team-high seven home runs.
• Among all MLB batters, Chapman ranks 30th in homers and 32nd in RBI.
• Michael Yastrzemski has seven doubles, five home runs and 17 walks while batting .283.
• Wilmer Flores paces the Giants in home runs (seven) and runs batted in (31).

Giants Team Props

Giants vs. Cubs Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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