Cubs vs. Cardinals Prediction, Odds, Picks - August 8

Kyle Tucker and the Chicago Cubs will meet Alec Burleson and the St. Louis Cardinals on Friday at Busch Stadium, at 8:15 p.m. ET. Oddsmakers list the Cubs as -169 moneyline favorites, while giving the underdog Cardinals +142 moneyline odds. Chicago (-1.5) is favored on the run line. The total is 8.5 runs for this matchup.

Take a look at everything you need from a betting perspective on the Cubs-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Cardinals Game Information & Odds

• When: Friday, August 8, 2025 at 8:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: MLB Network, FDSMW, and MARQ

Cubs vs. Cardinals Prediction

• Score Prediction: Cubs 6, Cardinals 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cubs 51%, Cardinals 49%

Cubs vs. Cardinals Betting Insights

• The Cubs have won 53, or 66.2%, of the 80 games they've played as favorites this season.
• This season Chicago has won 19 of its 27 games, or 70.4%, when favored by at least -169 on the moneyline.
• The implied probability of a win from the Cubs, based on the moneyline, is 62.8%.
• The Cardinals have been victorious in 30, or 49.2%, of the 61 contests they have been chosen as underdogs in this season.
• St. Louis has a mark of 5-10 in contests where sportsbooks favor it by +142 or worse on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 41.3% chance of coming away with a victory in the contest.

Cubs Recent Betting Performance

• The Cubs were favored on the moneyline for eight of their last 10 games, and they finished 4-4 in those matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Cubs and their opponents combined to hit the over four times.
• The Cubs' ATS record is 3-7-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Tucker is batting .271 with 21 doubles, four triples, 18 home runs and 75 walks.
• In all of MLB, Tucker is 48th in home runs and 48th in RBI.
• Pete Crow-Armstrong has shown off his power as he leads his team with 27 home runs.
• Including all MLB hitters, Crow-Armstrong is seventh in homers and ninth in RBI.
• Seiya Suzuki leads the Cubs in home runs (27) and runs batted in (84).
• Nico Hoerner is hitting .292 to lead his team.

Cubs Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in six of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over four times.
• Over their last 10 games, the Cardinals are 4-6-0 against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan paces the Cardinals with a team-leading batting average of .280.
• Donovan is 167th in homers and 134th in RBI among all batters in the big leagues.
• Burleson is batting .279 with 19 doubles, 14 home runs and 30 walks.
• Burleson is currently 93rd in home runs and 83rd in RBI in the big leagues.
• Willson Contreras has been a significant run producer for the Cardinals with 16 home runs and 64 runs batted in.
• Masyn Winn is hitting .270 with 24 doubles, eight home runs and 29 walks.

Cardinals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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