Cardinals vs. Pirates Prediction, Odds, Picks - May 5

Lars Nootbaar and the St. Louis Cardinals will square off against Andrew McCutchen and the Pittsburgh Pirates at Busch Stadium in the first of a three-game series, on Monday at 7:45 p.m. ET. The Cardinals have been listed as -134 moneyline favorites in this matchup with the Pirates (+114). St. Louis is the favorite on the run line (-1.5 with +151 odds). The over/under is 8.5 runs for the matchup (with -102 odds to hit the over and -119 odds to go under).

Check out everything you need from a betting perspective on the Cardinals-Pirates game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Padres vs. Pirates Highlights | MLB on FOX

Check out the best moments from the San Diego PAdres' 4-0 win over the Pittsburgh Pirates on Sunday, May 4th.

Cardinals vs. Pirates Game Information & Odds

• When: Monday, May 5, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and SportsNet PT

Cardinals vs. Pirates Prediction

• Score Prediction: Cardinals 6, Pirates 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cardinals 56%, Pirates 44%

Cardinals vs. Pirates Betting Insights

• The Cardinals have entered the game as favorites 10 times this season and won four of those games.
• This season St. Louis has won two of its four games when favored by at least -134 on the moneyline.
• The implied probability of a win from the Cardinals, based on the moneyline, is 57.3%.
• The Pirates have been underdogs in 21 games this season and have come away with the win seven times (33.3%) in those contests.
• Pittsburgh has a win-loss record of 4-10 when favored by +114 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Pirates have a 46.7% chance of walking away with the win.

Cardinals Recent Betting Performance

• The Cardinals were the moneyline favorite in four of their last 10 games, and they went 2-2 in those matchups.
• Over their last 10 matchups, the Cardinals and their opponents combined to hit the over six times (all 10 of the games had set totals).
• The Cardinals have a 4-6-0 record against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Nootbaar's five dingers in 2025 are the most on the Cardinals. He's also driven in 18 runs while hitting .244.
• Nootbaar ranks 57th in home runs and 47th in RBI among all batters in baseball.
• Brendan Donovan has a club-leading 19 runs batted in and .339 batting average.
• Donovan is 129th in home runs and 39th in RBI among all batters in MLB.
• Donovan has five straight games with at least one hit. In his last five games he is hitting .353 with three walks and three RBI.
• Nolan Arenado has nine doubles, three home runs and 15 walks while hitting .254.
• Arenado is on a two-game hitting streak entering this contest. In his last five games he is batting .250 with a walk and an RBI.
• Victor Scott II is hitting .286 with six doubles, a triple, two home runs and 12 walks.
• Scott is riding a five-game hitting streak into this one. In his last five games he is hitting .438 with a double, a home run, three walks and five RBI.

Cardinals Team Props

Pirates Recent Betting Performance

• In seven games as underdogs over the last 10 matchups, the Pirates have a record of 2-5.
• When it comes to hitting the over, the Pirates and their opponents are 5-5-0 in their last 10 games with a total.
• The Pirates have won three of their last 10 games against the spread.

Pirates Recent Stats

Pirates Player Insights

• Oneil Cruz leads the Pirates with eight long balls and runs batted in, driving in 18.
• In all of the majors, Cruz is 17th in homers and 47th in RBI.
• McCutchen has six doubles, three home runs and 13 walks while hitting .263.
• McCutchen is 129th in homers and 146th in RBI among all hitters in the majors.
• Bryan Reynolds is batting .232 with five doubles, four home runs and 13 walks.
• Ke'Bryan Hayes has two doubles, a triple, a home run and eight walks while batting .254.

Pirates Team Props

Padres vs. Pirates Highlights | MLB on FOX

Check out the best moments from the San Diego PAdres' 4-0 win over the Pittsburgh Pirates on Sunday, May 4th.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

St. Louis Cardinals

Pittsburgh Pirates