Cardinals vs. Giants Prediction, Odds, Picks - September 6

The San Francisco Giants and Rafael Devers hit the field against Lars Nootbaar and the St. Louis Cardinals on Saturday at Busch Stadium. The Giants are listed as -101 moneyline underdogs for this matchup against the favored Cardinals (-119). San Francisco (-1.5) is the favorite on the run line. The total is 8.5 runs for this matchup.

Here is everything you need to know from a betting perspective on the Cardinals-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Cardinals Highlights | MLB on FOX

Check out the best highlights between the St. Louis Cardinals and San Francisco Giants.

Cardinals vs. Giants Game Information & Odds

• When: Saturday, September 6, 2025 at 7:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FOX

Cardinals vs. Giants Prediction

• Score Prediction: Cardinals 5, Giants 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cardinals 51%, Giants 49%

Cardinals vs. Giants Betting Insights

• The Cardinals have entered the game as favorites 65 times this season and won 33, or 50.8%, of those games.
• St. Louis has entered 51 games this season favored by -119 or more and is 28-23 in those contests.
• The implied probability of a win from the Cardinals, based on the moneyline, is 54.3%.
• The Giants have been underdogs in 58 games this season and have come away with the win 28 times (48.3%) in those contests.
• This season, San Francisco has been victorious 22 times in 45 chances when named as an underdog of at least -101 or worse on the moneyline.
• The Giants have an implied victory probability of 50.2% according to the moneyline set for this matchup.

Cardinals Recent Betting Performance

• The Cardinals have a 2-4 record over the six games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups (all had set totals), the Cardinals combined with their opponents to go over the total five times.
• The Cardinals' record against the spread is 5-5-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Masyn Winn has 27 doubles, nine home runs and 33 walks while batting .253.
• Winn is 206th in homers and 140th in RBI among all hitters in the majors.
• Nootbaar is hitting .240 with 22 doubles, a triple, 13 home runs and 55 walks.
• Nootbaar is 145th in home runs in the majors, and 181st in RBI.
• Ivan Herrera is batting .283 with 11 doubles, 14 home runs and 34 walks.
• Victor Scott II has 14 doubles, a triple, five home runs and 38 walks while hitting .225.

Cardinals Team Props

Giants Recent Betting Performance

• In four games over the last 10 matchups when set as underdogs by bookmakers, the Giants had a record of 3-1.
• In their last 10 games with a total, the Giants and their opponents have combined to hit the over seven times.
• The Giants are 9-1-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Devers leads the Giants in home runs (31) and runs batted in (99).
• Among all hitters in the big leagues, Devers is 11th in home runs and seventh in RBI.
• Devers carries a five-game hitting streak into this matchup. In his last five games he is batting .391 with a double, four home runs, two walks and eight RBIs.
• Jung Hoo Lee is hitting .267 with 30 doubles, 11 triples, seven home runs and 44 walks.
• Lee is currently 247th in homers and 151st in RBI in the big leagues.
• Willy Adames is batting .230 with 18 doubles, two triples, 27 home runs and 66 walks.
• Heliot Ramos leads the Giants with a .269 batting average.

Giants Team Props

Giants vs. Cardinals Highlights | MLB on FOX

Check out the best highlights between the St. Louis Cardinals and San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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St. Louis Cardinals

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