Brewers vs. Reds Prediction, Odds, Picks - September 26

The Milwaukee Brewers and Cincinnati Reds will meet on Friday at American Family Field, at 8:10 p.m. ET, with Brice Turang and Elly De La Cruz among those expected to produce at the plate. Bookmakers list the Brewers as -166 moneyline favorites, while giving the underdog Reds +138 moneyline odds to win. Milwaukee is the run-line favorite (-1.5). The game's total is set at 8 runs.

Take a look at everything you need from a betting perspective on the Brewers-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Pirates vs. Reds Highlights | MLB on FOX

Enjoy the best moments between the Pittsburgh Pirates and the Cincinnati Reds.

Brewers vs. Reds Game Information & Odds

• When: Friday, September 26, 2025 at 8:10 p.m. ET
• Where: American Family Field in Milwaukee, Wisconsin
• How to watch on TV: FDSWI and FDSOH

Brewers vs. Reds Prediction

• Score Prediction: Brewers 4, Reds 3
• Total Prediction: Under 8 runs
• Win Probabilities: Brewers 58%, Reds 42%

Brewers vs. Reds Betting Insights

• The Brewers have been favorites in 94 games this season and won 59 (62.8%) of those contests.
• Milwaukee has a record of 19-4 in games when oddsmakers favor them by at least -166 on the moneyline.
• The moneyline for this contest implies a 62.4% chance of a victory for the Brewers.
• The Reds have been victorious in 41, or 49.4%, of the 83 contests they have been chosen as underdogs in this season.
• This year, Cincinnati has won nine of 21 games when listed as at least +138 or worse on the moneyline.
• The Reds have an implied victory probability of 42% according to the moneyline set by oddsmakers for this matchup.

Brewers Recent Betting Performance

• The Brewers were the moneyline favorite in nine of their last 10 games, and they finished 4-5 in those matchups.
• In their last 10 outings -- all had a set run total -- the Brewers and their opponents combined to hit the over on the total four times.
• The Brewers have gone 4-6-0 against the spread over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Turang is hitting .287 with 26 doubles, two triples, 18 home runs and 63 walks.
• Among all hitters in MLB, Turang's home run total places him 103rd, and his RBI tally ranks him 57th.
• William Contreras is batting .262 with 28 doubles, 17 home runs and 84 walks.
• Contreras is 111th in homers in the majors, and 63rd in RBI.
• Christian Yelich has put up a team-high 29 home runs and 102 runs batted in.
• Yelich is on a three-game hitting streak entering this contest. In his last five games he is batting .167 with three walks and two RBIs.
• Sal Frelick is batting .291 to lead his team.
• Frelick is riding a two-game hitting streak into this one. In his last five games he is hitting .174 with a double, a home run and two RBIs.

Brewers Team Props

Reds Recent Betting Performance

• Over the past 10 games, the Reds have been underdogs twice and won both contests.
• When it comes to hitting the over, the Reds and their opponents are 2-6-2 in their last 10 games with a total.
• The Reds have a record of 4-6-0 ATS over their last 10 games.

Reds Recent Stats

Reds Player Insights

• De La Cruz has a team-leading 21 home runs and has driven in 85 runs.
• In all of MLB, De La Cruz is 68th in homers and 34th in RBI.
• TJ Friedl has 21 doubles, two triples, 13 home runs and 79 walks while batting .259.
• Among all MLB batters, Friedl ranks 157th in home runs and 173rd in RBI.
• Spencer Steer leads the Reds with 21 long balls.
• Austin Hays has 16 doubles, five triples, 15 home runs and 29 walks while hitting .266.

Reds Team Props

Pirates vs. Reds Highlights | MLB on FOX

Enjoy the best moments between the Pittsburgh Pirates and the Cincinnati Reds.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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