Blue Jays vs. Orioles Prediction, Odds, Picks - March 27

Jose Berrios and Zach Eflin are the scheduled starters when the Toronto Blue Jays and Baltimore Orioles meet on Opening Day at Rogers Centre, at 3:07 p.m. ET. The Blue Jays are favored in this one, at -115, while the underdog Orioles have -105 odds to upset. Baltimore is a 1.5-run favorite (at +159 odds). The over/under is 8.5 runs for this contest (with -102 odds on the over and -118 odds on the under).

Check out everything you need from a betting perspective on the Blue Jays-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Addison Barger hit a walk-off home run that sealed the Toronto Blue Jays' 5-4 victory over the Los Angeles Angels.

Blue Jays vs. Orioles Game Information & Odds

• When: Thursday, March 27, 2025 at 3:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to Watch on TV: SNET and MASN2

Blue Jays vs. Orioles Prediction

• Score Prediction: Orioles 5, Blue Jays 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Blue Jays 50%, Orioles 50%

Blue Jays vs. Orioles Betting Insights

• The Blue Jays finished with a 44-36 record in games they were favored on the moneyline last season (winning 55% of those games).
• Toronto had a record of 40-33 in games it played as a moneyline favorite with odds of -115 or shorter last year (54.8%).
• The Blue Jays have a 53.5% chance to win this matchup based on the moneyline's implied probability.
• The Orioles were underdogs in 41 games last season and won 23 (56.1%) of those contests.

Blue Jays Player Insights

• Last season, Vladimir Guerrero Jr. drove in 103 runs while batting .323.
• Anthony Santander finished with a .506 SLG and 44 homers while driving in 102 runs.
• George Springer finished last season with 19 home runs, 56 RBI and a batting average of .220.
• Andres Gimenez collected 147 hits, posted an OBP of .298 and a .340 SLG.

Blue Jays Team Props

Orioles Player Insights

• Gunnar Henderson hit 37 home runs and had 92 runs batted in last season, while racking up a batting average of .281.
• Adley Rutschman had 21 doubles, a triple, 19 home runs and 58 walks while batting .250.
• Ryan O'Hearn hit .264 last season with 21 doubles, three triples, 15 home runs and 46 walks.
• Cedric Mullins hit .234 with 16 doubles, three triples, 18 home runs and 41 walks.

Orioles Team Props

Addison Barger's WALK-OFF home run seals Blue Jays' 5-4 victory over Angels

Addison Barger hit a walk-off home run that sealed the Toronto Blue Jays' 5-4 victory over the Los Angeles Angels.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Toronto Blue Jays

Baltimore Orioles