Astros vs. White Sox Prediction, Odds, Picks - June 12

Isaac Paredes and the Houston Astros take the field against Chase Meidroth and the Chicago White Sox on Thursday at 8:10 p.m. ET, in the final of a three-game series at Daikin Park. The favored Astros have -277 moneyline odds against the underdog White Sox, who are listed at +223. Houston is the run-line favorite (-1.5). A 7.5-run over/under is listed for this contest.

Here is everything you need to know from a betting perspective on the Astros-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Astros Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Houston Astros.

Astros vs. White Sox Game Information & Odds

• When: Thursday, June 12, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and CHSN

Astros vs. White Sox Prediction

• Score Prediction: Astros 4, White Sox 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Astros 60%, White Sox 40%

Astros vs. White Sox Betting Insights

• The Astros have won 26, or 56.5%, of the 46 games they've played as favorites this season.
• Houston has not been bigger favorites this season than the -277 moneyline set for this game.
• The Astros have a 73.5% chance to win this game based on the implied probability of the moneyline.
• The White Sox have been underdogs in 68 games this season and have come away with the win 23 times (33.8%) in those contests.
• This year, Chicago has won one of six games when listed as at least +223 or worse on the moneyline.
• The White Sox have an implied victory probability of 31% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros went 5-3 across the eight games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Astros and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Astros' ATS record is 5-5-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jeremy Pena is the Astros best hitter so far this season, hitting at a team-leading .322 rate along with nine homers and 33 RBI.
• Including all MLB hitters, Pena is seventh in batting average, 22nd in on-base percentage, and 27th in slugging.
• Pena carries a two-game hitting streak into this matchup. During his last five outings he is batting .364 with two doubles and two RBIs.
• Paredes has hit 14 home runs with 41 runs batted in. Both lead his team.
• Paredes ranks 15th in home runs and 24th in RBI among all hitters in baseball.
• Jose Altuve has seven doubles, nine home runs and 18 walks while batting .270.
• Altuve is on a two-game hitting streak entering this contest. In his last five games he is batting .333 with a double, a walk and three RBIs.
• Jake Meyers has 11 doubles, a triple, three home runs and 19 walks while batting .295.

Astros Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won five of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 6-4-0 in their last 10 games with a total.
• Over their last 10 games, the White Sox are 7-3-0 against the spread.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas leads the White Sox in home runs (nine), runs batted in (30) and has posted a team-best batting average of .233.
• In all of MLB, Vargas ranks 70th in homers and 91st in RBI.
• Meidroth has five doubles, two home runs and 23 walks while batting .296.
• Meidroth is 266th in homers and 303rd in RBI among all MLB hitters this season.
• Andrew Benintendi has seven doubles, a triple, six home runs and 15 walks while batting .242.
• Luis Robert is batting .185 with seven doubles, six home runs and 25 walks.

White Sox Team Props

White Sox vs. Astros Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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