Astros vs. White Sox Prediction, Odds, Picks - June 11

Ryan Gusto and the Houston Astros will hit the field against the Chicago White Sox and projected starter Sean Burke on Wednesday at Daikin Park. The Astros have been listed as -176 moneyline favorites in this matchup against the White Sox (+146). Houston is favored on the run line (-1.5). The game's total is set at 8 runs.

Here is everything you need to know from a betting perspective on the Astros-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Astros Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Houston Astros.

Astros vs. White Sox Game Information & Odds

• When: Wednesday, June 11, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and CHSN

Astros vs. White Sox Prediction

• Score Prediction: Astros 5, White Sox 4
• Total Prediction: Over 8 runs
• Win Probabilities: Astros 57%, White Sox 43%

Astros vs. White Sox Betting Insights

• The Astros have won 25, or 55.6%, of the 45 games they've played as favorites this season.
• Houston is 3-2 this season when entering a game favored by -176 or more on the moneyline.
• The oddsmakers' moneyline implies a 63.8% chance of a victory for the Astros.
• The White Sox have been chosen as underdogs in 67 games this year and have walked away with the win 23 times (34.3%) in those games.
• This season, Chicago has been victorious 12 times in 42 chances when named as an underdog of at least +146 or longer on the moneyline.
• The White Sox have an implied victory probability of 40.7% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros went 5-3 across the eight games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Astros combined with their opponents to hit the over on the total three times.
• The Astros' ATS record is 4-6-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jeremy Pena has accumulated a team-high batting average of .319.
• Of all hitters in baseball, Pena's home run total places him 68th, and his RBI tally puts him 72nd.
• Isaac Paredes' 14 home runs and 39 runs batted in both pace his team.
• Paredes ranks 15th in homers and 30th in RBI among all batters in the majors.
• Jose Altuve has six doubles, nine home runs and 18 walks while batting .266.
• Jake Meyers has 11 doubles, a triple, three home runs and 19 walks while hitting .300.
• Meyers takes a four-game streak with at least one hit into this one. In his last five games he is hitting .389 with a double and three walks.

Astros Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and have gone 5-5 in those contests.
• In their last 10 games with a total, the White Sox and their opponents are 5-5-0 when it comes to hitting the over.
• The White Sox have a record of 7-3-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas leads the White Sox in home runs (nine) and runs batted in (29).
• Among all hitters in the big leagues, Vargas' home run total ranks 68th and his RBI tally ranks 93rd.
• Chase Meidroth is hitting .293 with five doubles, two home runs and 23 walks.
• Meidroth ranks 264th overall in home runs and 301st in RBI this year.
• Andrew Benintendi has six doubles, a triple, six home runs and 15 walks while hitting .241.
• Luis Robert is batting .184 with seven doubles, six home runs and 25 walks.

White Sox Team Props

White Sox vs. Astros Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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