Astros vs. Rays Prediction, Odds, Picks - May 21

Isaac Paredes and the Houston Astros will try to defeat Yandy Diaz and the Tampa Bay Rays at George M. Steinbrenner Field on Wednesday at 1:10 p.m. ET. The Astros are favored in this one, at -159, while the underdog Rays have +135 odds to upset. Houston is a 1.5-run favorite (at +105 odds). The total for the matchup is set at 8.5 runs.

Take a look at everything you need from a betting perspective on the Astros-Rays game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Rays Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Tampa Bay Rays.

Astros vs. Rays Game Information & Odds

• When: Wednesday, May 21, 2025 at 1:10 p.m. ET
• Where: George M. Steinbrenner Field in Tampa, Florida
• How to watch on TV: FDSSUN and SCHN

Astros vs. Rays Prediction

• Score Prediction: Astros 5, Rays 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Astros 50%, Rays 50%

Astros vs. Rays Betting Insights

• The Astros have won 18, or 56.2%, of the 32 games they've played as favorites this season.
• Houston has a record of 4-4 in games when oddsmakers favor them by at least -159 on the moneyline.
• The Astros have a 61.4% chance to win this game based on the implied probability of the moneyline.
• The Rays have been victorious in 10, or 47.6%, of the 21 contests they have been chosen as underdogs in this season.
• This year, Tampa Bay has won five of 11 games when listed as at least +135 or worse on the moneyline.
• The Rays have an implied victory probability of 42.6% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros were the moneyline favorite for five of their last 10 games, and they went 4-1 in those matchups.
• In their last 10 outings (all had set totals), the Astros combined with their opponents to go over the run total two times.
• The Astros are 5-5-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Paredes leads the Astros in home runs (eight) and runs batted in (25).
• Paredes is 41st in homers and 58th in RBI among all hitters in the majors.
• Paredes has collected a hit in five games in a row. In his last five games he is batting .300 with two home runs, two walks and six RBIs.
• Jeremy Pena has eight doubles, six home runs and 13 walks while hitting .302.
• Pena is 81st in home runs and 74th in RBI on the year.
• Jake Meyers leads the Astros with a team-best batting average of .307.
• Meyers will look to build on his five-game hitting in this game. During his last five outings he is hitting .412 with a double, a home run, three walks and two RBIs.
• Jose Altuve has six doubles, four home runs and 14 walks while hitting .242.

Astros Team Props

Rays Recent Betting Performance

• The Rays have played as underdogs in three of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Rays and their opponents are 3-7-0 when it comes to hitting the over.
• The Rays have three wins against the spread in their last 10 chances.

Rays Recent Stats

Rays Player Insights

• Diaz has collected a team-leading 24 runs batted in.
• In all of MLB, Diaz is 81st in homers and 67th in RBI.
• Diaz carries a five-game hitting streak into this matchup. During his last five outings he is hitting .350 with a double, a walk and four RBIs.
• Jonathan Aranda is hitting .310 to lead the lineup.
• Aranda ranks 81st in home runs and 74th in RBI among all major league hitters this year.
• Junior Caminero leads the Rays with eight long balls.
• Brandon Lowe has racked up a team-leading 24 runs batted in.

Rays Team Props

Astros vs. Rays Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Tampa Bay Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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