Astros vs. Pirates Prediction, Odds, Picks - June 5

Jeremy Pena and the Houston Astros will see Mitch Keller on the hill for the Pittsburgh Pirates in the final game of a three-game series, Thursday at 6:40 p.m. ET. The Astros are the favorite in this one, at -141, while the underdog Pirates have +120 odds to upset. Houston is the run-line favorite (-1.5). The total for the matchup has been listed at 7.5 runs.

Take a look at everything you need from a betting perspective on the Astros-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Pittsburgh Pirates.

Astros vs. Pirates Game Information & Odds

• When: Thursday, June 5, 2025 at 6:40 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: SportsNet PT and SCHN

Astros vs. Pirates Prediction

• Score Prediction: Astros 5, Pirates 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 51%, Pirates 49%

Astros vs. Pirates Betting Insights

• This season, the Astros have been favored 41 times and won 22, or 53.7%, of those games.
• This season Houston has won 11 of its 18 games, or 61.1%, when favored by at least -141 on the moneyline.
• The Astros have a 58.5% chance to win this game based on the implied probability of the moneyline.
• The Pirates have come away with 17 wins in the 44 contests they have been listed as the underdogs in this season.
• Pittsburgh has a mark of 10-20 in contests where bookmakers favor it by +120 or worse on the moneyline.
• The moneyline set for this matchup implies the Pirates have a 45.5% chance of coming away with a victory in the contest.

Astros Recent Betting Performance

• The Astros went 4-3 over the seven games they were moneyline favorites in their last 10 matchups.
• In their last 10 outings, the Astros and their opponents combined to go over the run total three times (all 10 of the games had set totals).
• The Astros are 5-5-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Pena paces the Astros with a .312 batting average.
• In all of MLB, Pena ranks 57th in homers and 70th in RBI.
• Pena takes a hitting streak of 10 games into this game. In his last 10 games he is batting .410 with two doubles, three home runs, three walks and five RBIs.
• Isaac Paredes has shown off his power as he leads his team with 12 home runs and 34 RBI.
• Paredes is 23rd in home runs and 41st in RBI in the major leagues.
• Jose Altuve is hitting .264 with six doubles, nine home runs and 17 walks.
• Altuve will look to build on his two-game hitting in this matchup. In his last five games he is hitting .222 with a walk.
• Jake Meyers has 10 doubles, a triple, three home runs and 16 walks while batting .292.
• Meyers is riding a four-game hitting streak into this one. In his last five games he is hitting .278 with two doubles.

Astros Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in nine of their past 10 games and won five of those contests.
• In their last 10 games with a total, the Pirates and their opponents have combined to hit the over four times.
• The Pirates have a record of 7-3-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Oneil Cruz has racked up a team-best 12 home runs.
• Cruz is 23rd in homers and 97th in RBI among all hitters in MLB.
• Bryan Reynolds has racked up 34 runs batted in to lead his team.
• Reynolds is 92nd among all batters in MLB in homers, and 41st in RBI.
• Andrew McCutchen leads the Pirates with a team-high batting average of .254.
• Isiah Kiner-Falefa is batting .304 with nine doubles, a triple, a home run and nine walks.

Pirates Team Props

Astros vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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