Astros vs. Padres Prediction, Odds, Picks - April 18

Isaac Paredes and the Houston Astros will try to defeat Fernando Tatis Jr. and the San Diego Padres at Daikin Park on Friday at 8:10 p.m. ET. The Astros are favored in this one, at -159, while the underdog Padres have +134 odds to win. Houston is a 1.5-run favorite (at +132 odds). The total for the game has been listed at 9 runs.

Take a look at everything you need from a betting perspective on the Astros-Padres game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Cubs vs. Padres Highlights | MLB on FOX

Check out the best moments between the Chicago Cubs and the San Diego Padres.

Astros vs. Padres Game Information & Odds

• When: Friday, April 18, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and SDPA

Astros vs. Padres Prediction

• Score Prediction: Padres 5, Astros 4
• Total Prediction: Under 9 runs
• Win Probabilities: Astros 54%, Padres 46%

Astros vs. Padres Betting Insights

• This season, the Astros have been favored 11 times and won five, or 45.5%, of those games.
• Houston has a record of 1-2 when favored by -159 or more by bookmakers this season.
• The implied probability of a win from the Astros, based on the moneyline, is 61.4%.
• The Padres have been victorious in four of the seven contests they have been chosen as underdogs in this season.
• San Diego has played as an underdog of +134 or more just one time this year and came away with a loss in that game.
• The moneyline set for this matchup implies the Padres have a 42.7% chance of walking away with the win.

Astros Recent Betting Performance

• The Astros were favored on the moneyline for six of their last 10 games, and they went 3-3 in those matchups.
• In their last 10 outings, the Astros and their opponents combined to go over the total five times (all 10 games had set totals).
• The Astros' ATS record is 6-4-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Carlos Altuve's .311 average and three homers both put him atop the Astros leaderboard this season.
• In all of MLB, Altuve is 57th in home runs and 128th in RBI.
• Altuve has collected a hit in two games in a row. In his last five games he is batting .167 with a double and an RBI.
• Jeremy Pena's three home runs pace his team.
• Pena ranks 57th in homers and 128th in RBI in the bigs.
• Pena heads into this matchup looking for his ninth game in a row with a hit. In his last 10 games he is hitting .237 with two doubles, a home run, four walks and five RBI.
• Paredes paces the Astros with three home runs and 10 runs batted in.
• Yordan Ruben Alvarez's 10 runs batted in lead his team.

Astros Team Props

Padres Recent Betting Performance

• In three games over the last 10 matchups when set as underdogs by oddsmakers, the Padres had a record of 2-1.
• In their last 10 games with a total, the Padres and their opponents have failed to hit the over five times.
• The Padres have a record of 8-2-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis leads the Padres with six home runs and 14 runs batted in, while recording a team-best batting average of .348.
• Tatis ranks fourth in home runs and 19th in RBI among all hitters in the big leagues.
• Tatis has collected a hit in six straight games. During his last 10 outings he is hitting .282 with five home runs, six walks and nine RBI.
• Manny Machado has eight doubles, two home runs and eight walks while batting .324.
• Machado is 100th overall in homers and 84th in RBI this season.
• Luis Sangel (Reveron) Arraez is batting .275 with three doubles, two home runs and three walks.
• Xander Bogaerts is batting .258 with six doubles and 10 walks.

Padres Team Props

Astros vs Cardinals Highlights | MLB on FOX

Check out the best moments between the Houston Astros and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Houston Astros

San Diego Padres