Astros vs. Orioles Prediction, Odds, Picks - August 16

Jordan Westburg and the Baltimore Orioles take on Jeremy Pena and the Houston Astros at Daikin Park on Saturday at 7:10 p.m. ET. The favored Astros have -225 moneyline odds to win against the underdog Orioles, who are listed at +185. Houston is the run-line favorite (-1.5). The game's over/under is listed at 7.5 runs.

Here's everything you need from a betting perspective on the Astros-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Orioles Game Information & Odds

• When: Saturday, August 16, 2025 at 7:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and MASN2

Astros vs. Orioles Prediction

• Score Prediction: Astros 4, Orioles 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Astros 57%, Orioles 43%

Astros vs. Orioles Betting Insights

• This season, the Astros have been favored 83 times and won 44, or 53%, of those games.
• Houston has a record of 4-3 when favored by -225 or more by sportsbooks this season.
• Oddsmakers have implied with the moneyline set for this matchup that the Astros have a 69.2% chance to win.
• The Orioles have been underdogs in 63 games this season and have come away with the win 29 times (46%) in those contests.
• Baltimore has a mark of 2-1 in contests where sportsbooks favor it by +185 or worse on the moneyline.
• The Orioles have an implied victory probability of 35.1% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros went 2-3 over the five games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings, the Astros and their opponents combined to go over the run total seven times (all 10 games had set totals).
• The Astros' ATS record is 6-4-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve leads the Astros with 21 round-trippers on the year. He's also hitting .281 with 63 RBI.
• Among all MLB hitters, Altuve is 26th in batting average, 51st in on-base percentage, and 45th in slugging.
• Pena is hitting .318 to lead his team.
• Pena ranks 114th in homers and 133rd in RBI in the major leagues.
• Pena enters this matchup looking for his fourth game in a row with a hit. During his last five outings he is hitting .273 with two home runs, a walk and two RBIs.
• Yainer Diaz has 16 doubles, a triple, 17 home runs and 15 walks while hitting .252.
• Christian Walker's 65 runs batted in are a team-high mark.

Astros Team Props

Orioles Recent Betting Performance

• In seven games over the last 10 matchups when set as underdogs by sportsbooks, the Orioles had a record of 4-3.
• The Orioles and their opponents have combined to hit the over two times in their last 10 games with a total.
• The Orioles have a record of 7-3-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson leads the lineup with a batting average of .283, and leads the Orioles in home runs, with 14 and runs batted in with 53.
• Henderson's home run total places him 101st in the big leagues, and he is 90th in RBI.
• Henderson has collected a hit in eight games in a row. In his last 10 games he is hitting .257 with four doubles, a home run, two walks and six RBIs.
• Jackson Holliday has shown his power as he leads his team with 14 home runs.
• Holliday ranks 101st in home runs and 133rd in RBI among all hitters in the majors.
• Adley Rutschman is hitting .232 with 16 doubles, a triple, nine home runs and 37 walks.
• Westburg has swatted a team-leading 14 home runs.

Orioles Team Props

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Check out the best moments between the Seattle Mariners and Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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