Astros vs. Cardinals Prediction, Odds, Picks - April 14

Brendan Donovan and the St. Louis Cardinals hit the field on Monday at Busch Stadium against Framber Valdez, who gets the start for the Houston Astros. First pitch is at 7:45 p.m. ET for the first game of a three-game series. The Astros are listed as -112 moneyline favorites for this matchup with the Cardinals (-107). Houston is the run-line favorite (-1.5). The over/under is 7 runs for this game (with -117 odds on the over and -102 odds to go under).

Here's everything you need to know from a betting perspective on the Astros-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Phillies vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Philadelphia Phillies and the St. Louis Cardinals.

Astros vs. Cardinals Game Information & Odds

• When: Monday, April 14, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and SCHN

Astros vs. Cardinals Prediction

• Score Prediction: Astros 5, Cardinals 4
• Total Prediction: Over 7 runs
• Win Probabilities: Astros 50%, Cardinals 50%

Astros vs. Cardinals Betting Insights

• This season, the Astros have won four out of the nine games in which they've been favored.
• Houston has a record of 4-5 in games when bookmakers favor them by at least -112 on the moneyline.
• The oddsmakers' moneyline implies a 52.8% chance of a victory for the Astros.
• The Cardinals have been chosen as underdogs in 10 games this year and have walked away with the win six times (60%) in those games.
• This season, St. Louis has come away with a win four times in eight chances when named as an underdog of at least -107 or longer on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 51.7% chance of coming away with a victory in the contest.

Astros Recent Betting Performance

• The Astros have a 2-3 record over the five games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings -- all had a set run total -- the Astros and their opponents combined to hit the over on the total five times.
• The Astros' ATS record is 6-4-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• The Astros leader in both batting average and long balls is Jose Altuve, who comes into the matchup hitting .302 and has left the yard three times while driving in seven runs this season.
• Altuve's home runs place him 38th in the majors, and he ranks 93rd in RBI.
• Isaac Paredes has hit three home runs with nine RBI. Both lead his team.
• Paredes ranks 38th in home runs and 49th in RBI among all batters in MLB.
• Paredes heads into this matchup looking for his sixth game in a row with a hit. During his last five outings he is batting .381 with three home runs, three walks and five RBI.
• Jeremy Pena is batting .204 with a double, two home runs and five walks.
• Pena will look to build on his five-game hitting in this game. In his last five games he is hitting .316 with a double, three walks and two RBI.
• Yordan Alvarez's nine runs batted in pace his team.
• Alvarez brings a five-game streak with at least one hit into this one. In his last five games he is batting .353 with a double, four walks and two RBI.

Astros Team Props

Cardinals Recent Betting Performance

• In seven games as underdogs over the last 10 matchups, the Cardinals have a record of 3-4.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over five times.
• Over their last 10 games, the Cardinals are 5-5-0 against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Donovan leads the Cardinals with a .350 batting average.
• Among all hitters in the majors, Donovan's home run total is 74th and his RBI tally ranks 32nd.
• Donovan carries a nine-game hitting streak into this matchup. In his last 10 outings he is hitting .400 with four doubles, a home run, two walks and seven RBI.
• Nolan Arenado has four doubles, a home run and nine walks while batting .283.
• Among all MLB hitters, Arenado is 122nd in home runs and 93rd in RBI.
• Lars Nootbaar has a double, two home runs and 11 walks while batting .259.
• Victor Scott II has two doubles, a triple, a home run and five walks while batting .275.

Cardinals Team Props

Phillies vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Philadelphia Phillies and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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