USC vs. Iowa Prediction, Odds, Picks - November 15, 2025

Updated Nov. 15, 2025 3:04 p.m. ET

Data Skrive

The No. 17 USC Trojans (7-2) bring the 10th-ranked passing attack in college football into a matchup with the Iowa Hawkeyes (6-3), who have the No. 5 passing defense, on Saturday, November 15, 2025. The Trojans are 6.5-point favorites. The over/under is set at 48.5 points for the game.

The Trojans' last game was versus the Northwestern Wildcats, and they won by a score of 38-17. In their last contest, the Hawkeyes lost versus the Oregon Ducks, 18-16.

Keep up with college football all season on FOX Sports.

USC vs. Iowa Game Information & Odds

When: Saturday, November 15, 2025 at 3:30 p.m. ET
Location: Los Angeles Memorial Coliseum in Los Angeles, California
TV: BTN
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

USC vs Iowa Betting Information updated as of November 15, 2025, 2:46 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-6.5 (-115)	-240	+196	48.5	-109	-110

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USC vs. Iowa Prediction

Pick ATS: USC (-6.5)
Pick OU: Over (48.5)
Prediction: USC 30, Iowa 22

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Iowa Hawkeyes game on FOX Sports!

USC vs. Iowa Betting Insights

Based on the spread and over/under, the implied score for the tilt is Trojans 28, Hawkeyes 21.
The Trojans have a 70.6% chance to collect the win in this contest per the moneyline's implied probability. The Hawkeyes hold a 33.8% implied probability.
USC has compiled a 5-4-0 record against the spread this season.
Iowa is 6-2-1 ATS this year.

USC vs. Iowa: 2025 Stats Comparison

	USC	Iowa
Off. Points per Game (Rank)	39.6 (12)	29.6 (65)
Def. Points per Game (Rank)	21.8 (32)	13.7 (4)
Turnovers Allowed (Rank)	12 (69)	8 (13)
Turnovers Forced (Rank)	15 (33)	12 (59)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	2,614 YDS (66.2%) / 17 TD / 6 INT 113 RUSH YDS / 6 RUSH TD / 12.6 RUSH YPG
Makai Lemon	WR	61 REC / 937 YDS / 7 TD / 104.1 YPG
King Miller	RB	636 YDS / 5 TD / 90.9 YPG / 8 YPC
Waymond Jordan	RB	576 YDS / 5 TD / 96 YPG / 6.5 YPC
Eric Gentry	LB	39 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	29 TKL / 2 TFL / 1 SACK / 5 INT
Anthony Lucas	DL	21 TKL / 3 TFL / 3 SACK
Kameryn Fountain	DL	14 TKL / 5 TFL / 3.5 SACK

Iowa 2025 Key Players

Name	Position	Stats
Mark Gronowski	QB	1,084 YDS (63.9%) / 5 TD / 4 INT 338 RUSH YDS / 12 RUSH TD / 37.6 RUSH YPG
Kamari Moulton	RB	522 YDS / 2 TD / 74.6 YPG / 5 YPC 12 REC / 80 REC YDS / 0 REC TD / 16 REC YPG
Kaden Wetjen	WR	17 REC / 132 YDS / 1 TD / 16.5 YPG
Xavier Williams	RB	255 YDS / 3 TD / 36.4 YPG / 6.2 YPC
Zach Lutmer	DB	47 TKL / 2 TFL / 1 SACK / 2 INT
Max Llewellyn	DL	20 TKL / 7 TFL / 6 SACK
Karson Sharar	LB	55 TKL / 4 TFL / 1 SACK
Xavier Nwankpa	DB	50 TKL / 0 TFL / 1 INT / 1 PD