Oregon vs. Oregon State Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 9:04 a.m. ET

Data Skrive

The No. 6 Oregon Ducks (3-0) are big 34.5-point favorites on Saturday, September 20, 2025 against the Oregon State Beavers (0-3). A 56.5-point over/under is set for the contest.

Against the Northwestern Wildcats in their most recent contest, the Ducks won 34-14. The Beavers' last contest was against the Texas Tech Red Raiders, and they lost by a score of 45-14.

Keep up with college football all season on FOX Sports.

Oregon vs. Oregon State Game Information & Odds

When: Saturday, September 20, 2025 at 3 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: BTN
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Oregon vs Oregon State Betting Information updated as of September 20, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-34.5 (-107)	N/A	N/A	56.5	-110	-111

Oregon vs. Oregon State Prediction

Pick ATS: Oregon State (+34.5)
Pick OU: Over (56.5)
Prediction: Oregon 37, Oregon State 22

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the Oregon State Beavers game on FOX Sports!

Oregon vs. Oregon State Betting Insights

Based on the spread and over/under, the implied score for the tilt is Ducks 46, Beavers 11.
Oregon has won two games against the spread this season.
Oregon State is winless against the spread this season (0-3-0).

Oregon vs. Oregon State: Head-to-Head

Oregon has a 3-1 record against Oregon State in their last four matchups.
The Ducks have a 3-1 record ATS in those games, while the two teams have gone over the total on three occasions.
In their last four head-to-head matchups, Oregon has tallied 152 points versus Oregon State, while allowing only 88 points.

Oregon vs. Oregon State: 2025 Stats Comparison

	Oregon	Oregon State
Off. Points per Game (Rank)	54 (4)	18.7 (113)
Def. Points per Game (Rank)	10 (15)	38.3 (128)
Turnovers Allowed (Rank)	1 (10)	6 (117)
Turnovers Forced (Rank)	4 (47)	3 (69)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	657 YDS (78.1%) / 7 TD / 1 INT 34 RUSH YDS / 0 RUSH TD / 11.3 RUSH YPG
Jordon Davison	RB	40 YDS / 5 TD / 13.3 YPG / 3.1 YPC
Jayden Limar	RB	145 YDS / 3 TD / 48.3 YPG / 7.3 YPC
Dakorien Moore	WR	9 REC / 144 YDS / 1 TD / 48 YPG
Matayo Uiagalelei	LB	6 TKL / 3 TFL / 3 SACK
Bryce Boettcher	LB	17 TKL / 0 TFL / 1 INT / 1 PD
Teitum Tuioti	LB	15 TKL / 1 TFL / 1.5 SACK
Jerry Mixon	LB	10 TKL / 1 TFL / 2 INT / 2 PD

Oregon State 2025 Key Players

Name	Position	Stats
Maalik Murphy	QB	896 YDS (61.6%) / 6 TD / 5 INT -20 RUSH YDS / 1 RUSH TD / -6.7 RUSH YPG
Trent Walker	WR	23 REC / 302 YDS / 0 TD / 100.7 YPG
Anthony Hankerson	RB	190 YDS / 1 TD / 63.3 YPG / 3.7 YPC
Tastean Reddicks	WR	15 REC / 213 YDS / 0 TD / 71 YPG
Skyler Thomas	DB	14 TKL / 0 TFL / 1 INT / 1 PD
Dexter Foster	LB	17 TKL / 1 TFL
Sailasa Vadrawale	DB	11 TKL / 1 TFL
Tahjae Mullix	DL	4 TKL / 2 TFL / 1 SACK