Oregon vs. Northwestern Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 9:04 a.m. ET

Data Skrive

Oddsmakers heavily favor the No. 4 Oregon Ducks (2-0) when they visit the Northwestern Wildcats (1-1) on Saturday, September 13, 2025 in a matchup between Big Ten rivals at Northwestern Medicine Field at Martin Stadium. Oregon is favored by 27.5 points. The point total is 48.5.

In their last action, the Ducks won versus the Oklahoma State Cowboys, 69-3. The Wildcats' most recent contest was versus the Western Illinois Leathernecks, and they won by a score of 42-7.

Keep up with college football all season on FOX Sports.

Joel Klatt on Caleb Williams, Michigan, Oregon a Top 5 program? | FULL INTERVIEW | The Herd

FOX Sports' Joel Klatt joins Colin Cowherd to break down Caleb Williams and J.J. McCarthy's performances on Monday Night Football, then dives into how concerned fans should be over Michigan's offense and Bryce Underwood. He then reacts to Steve Sarkisian's comments regarding Arch Manning's throwing grimaces. Klatt and Colin then discuss whether Oregon is a Top 5 CFB program or not, along with why USC is a team to watch.

Oregon vs. Northwestern Game Information & Odds

When: Saturday, September 13, 2025 at 12 p.m. ET
Location: Northwestern Medicine Field at Martin Stadium in Evanston, Illinois
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Oregon vs Northwestern Betting Information updated as of September 13, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-27.5 (-102)	-5556	+1770	48.5	-112	-109

Oregon vs. Northwestern Prediction

Pick ATS: Northwestern (+27.5)
Pick OU: Over (48.5)
Prediction: Oregon 28, Northwestern 21

Predictions are made by the Data Skrive betting model.

Learn more about the Oregon Ducks vs. the Northwestern Wildcats game on FOX Sports!

Oregon vs. Northwestern Betting Insights

Based on the spread and over/under, the implied score for the tilt is Ducks 38, Wildcats 10.
The Ducks have a 98.2% chance to collect the win in this contest per the moneyline's implied probability. The Wildcats hold a 5.3% implied probability.
Oregon has covered in each of its two games with a spread this season.
Northwestern has covered once in two games with a spread this season.

Oregon vs. Northwestern: 2025 Stats Comparison

	Oregon	Northwestern
Off. Points per Game (Rank)	64 (4)	22.5 (99)
Def. Points per Game (Rank)	8 (10)	15 (47)
Turnovers Allowed (Rank)	0 (1)	6 (129)
Turnovers Forced (Rank)	2 (64)	1 (96)

Oregon 2025 Key Players

Name	Position	Stats
Dante Moore	QB	479 YDS (77.3%) / 6 TD / 0 INT 29 RUSH YDS / 0 RUSH TD / 14.5 RUSH YPG
Noah Whittington	RB	159 YDS / 2 TD / 79.5 YPG / 11.4 YPC
Jordon Davison	RB	32 YDS / 4 TD / 16 YPG / 3.6 YPC
Dakorien Moore	WR	5 REC / 95 YDS / 1 TD / 47.5 YPG
Matayo Uiagalelei	LB	3 TKL / 2 TFL / 2 SACK
Teitum Tuioti	LB	9 TKL / 1 TFL / 1 SACK
Peyton Woodyard	DB	7 TKL / 0 TFL / 1 INT / 1 PD
Bryce Boettcher	LB	12 TKL / 0 TFL

Northwestern 2025 Key Players

Name	Position	Stats
Cam Porter	RB	137 YDS / 1 TD / 68.5 YPG / 7.6 YPC 3 REC / 23 REC YDS / 0 REC TD / 23 REC YPG
Griffin Wilde	WR	11 REC / 158 YDS / 0 TD / 79 YPG
Preston Stone	QB	406 YDS (61.5%) / 3 TD / 4 INT
Ryan Boe	QB	YDS (%) / TD / INT 58 RUSH YDS / 1 RUSH TD / 58 RUSH YPG
Mac Uihlein	LB	12 TKL / 2 TFL / 1 INT / 1 PD
Robert Fitzgerald	DB	16 TKL / 0 TFL
Carmine Bastone	DL	6 TKL / 1 TFL / 1.5 SACK
Aidan Hubbard	DL	4 TKL / 1 TFL / 1 SACK