Ole Miss vs. LSU Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

The No. 4 LSU Tigers (4-0) and the 10th-ranked run defense will visit the No. 13 Ole Miss Rebels (4-0) and the 24th-ranked run offense on Saturday, September 27, 2025. The Tigers are just 2.5-point underdogs. The game has a 57.5-point over/under.

The Rebels' most recent game was versus the Tulane Green Wave, and they won by a score of 45-10. Last time around, the Tigers defeated the Southeastern Louisiana Lions, with 56-10 being the final score.

Keep up with college football all season on FOX Sports.

Ole Miss vs. LSU Game Information & Odds

When: Saturday, September 27, 2025 at 3:30 p.m. ET
Location: Vaught-Hemingway Stadium in Oxford, Mississippi
TV: ABC
Live Box Score on FOX Sports

Ole Miss vs LSU Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ole Miss	-2.5 (-107)	-129	+109	57.5	-113	-107

Ole Miss vs. LSU Prediction

Pick ATS: Ole Miss (-2.5)
Pick OU: Under (57.5)
Prediction: Ole Miss 33, LSU 13

Predictions are made by the Data Skrive betting model.

Learn more about the Ole Miss Rebels vs. the LSU Tigers game on FOX Sports!

Ole Miss vs. LSU Betting Insights

Based on the spread and over/under, the implied score for the game is Rebels 30, Tigers 28.
The Rebels have a 56.3% chance to win this meeting per the moneyline's implied probability. The Tigers hold a 47.8% implied probability.
Ole Miss is 3-1-0 ATS this season.
LSU has a record of 2-2-0 against the spread this season.

Ole Miss vs. LSU: Head-to-Head

In their past four matchups, LSU has a split 2-2 record against Ole Miss.
The Rebels and the Tigers have matched up evenly over their last four games, sporting a split 2-2 record against the spread. In those four games, the two teams have gone over the point total on two occasions.
In their last four head-to-head matchups, LSU has tallied 140 points against Ole Miss, while giving up only 132 points.

Ole Miss vs. LSU: 2025 Stats Comparison

	Ole Miss	LSU
Off. Points per Game (Rank)	44.8 (11)	29 (67)
Def. Points per Game (Rank)	18.8 (49)	9.3 (10)
Turnovers Allowed (Rank)	5 (74)	4 (50)
Turnovers Forced (Rank)	3 (96)	6 (27)

Ole Miss 2025 Key Players

Name	Position	Stats
Kewan Lacy	RB	358 YDS / 7 TD / 89.5 YPG / 4.5 YPC 8 REC / 47 REC YDS / 0 REC TD / 15.7 REC YPG
Trinidad Chambliss	QB	719 YDS (67.7%) / 4 TD / 0 INT 195 RUSH YDS / 2 RUSH TD / 48.8 RUSH YPG
Harrison Wallace III	WR	16 REC / 343 YDS / 2 TD / 85.8 YPG
Austin Simmons	QB	580 YDS (60.7%) / 4 TD / 4 INT 69 RUSH YDS / 1 RUSH TD / 23 RUSH YPG
Zxavian Harris	DL	21 TKL / 4 TFL / 2 SACK / 1 INT
T.J. Dudley	LB	25 TKL / 0 TFL
Jaden Yates	LB	28 TKL / 0 TFL
William Echoles	DL	19 TKL / 1 TFL / 1 SACK

LSU 2025 Key Players

Name	Position	Stats
Garrett Nussmeier	QB	960 YDS (68.6%) / 6 TD / 2 INT -10 RUSH YDS / 1 RUSH TD / -2.5 RUSH YPG
Caden Durham	RB	213 YDS / 2 TD / 53.3 YPG / 4.1 YPC
Zavion Thomas	WR	11 REC / 115 YDS / 2 TD / 28.8 YPG
Aaron Anderson	WR	21 REC / 293 YDS / 0 TD / 73.3 YPG
West Weeks	LB	24 TKL / 1 TFL / 0.5 SACK
Davhon Keys	LB	23 TKL / 0 TFL / 0.5 SACK
Tamarcus Cooley	DB	18 TKL / 0 TFL / 1 INT / 1 PD
Harold Perkins	LB	13 TKL / 1 TFL / 1 SACK