Old Dominion vs. Liberty Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

Data Skrive

The Old Dominion Monarchs (2-1) are an overwhelming 14.5-point favorite heading into their matchup on Saturday, September 27, 2025 against the Liberty Flames (1-3). The game has an over/under of 53.5 points.

Against the Virginia Tech Hokies in their most recent contest, the Monarchs won 45-26. In their last game, the Flames lost versus the James Madison Dukes, 31-13.

Keep up with college football all season on FOX Sports.

Old Dominion vs. Liberty Game Information & Odds

When: Saturday, September 27, 2025 at 6 p.m. ET
Location: Kornblau Field at S.B. Ballard Stadium in Norfolk, Virginia
TV: ESPN+
Live Box Score on FOX Sports

Old Dominion vs Liberty Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Old Dominion	-14.5 (-110)	-637	+462	53.5	-112	-108

Old Dominion vs. Liberty Prediction

Pick ATS: Old Dominion (-14.5)
Pick OU: Under (53.5)
Prediction: Old Dominion 54, Liberty -3

Predictions are made by the Data Skrive betting model.

Learn more about the Old Dominion Monarchs vs. the Liberty Flames game on FOX Sports!

Old Dominion vs. Liberty Betting Insights

Based on the spread and over/under, the implied score for the game is Monarchs 34, Flames 20.
The Monarchs have an 86.4% chance to win this game based on the moneyline's implied probability. The Flames hold a 17.8% implied probability.
Old Dominion has covered in each of its three games with a spread this season.
Liberty is winless against the spread this season (0-4-0).

Old Dominion vs. Liberty: Head-to-Head

Liberty has a 3-0 record against Old Dominion in their last three matchups.
In those matchups against Old Dominion, the Flames have covered three times while outscoring the total on two occasions.
Over their last three head-to-head contests, Liberty has put up 121 points, while Old Dominion has posted 51.

Old Dominion vs. Liberty: 2025 Stats Comparison

	Old Dominion	Liberty
Off. Points per Game (Rank)	37.7 (69)	19.5 (113)
Def. Points per Game (Rank)	19.7 (32)	23.8 (78)
Turnovers Allowed (Rank)	5 (74)	6 (96)
Turnovers Forced (Rank)	7 (14)	3 (96)

Old Dominion 2025 Key Players

Name	Position	Stats
Colton Joseph	QB	629 YDS (67.6%) / 5 TD / 3 INT 294 RUSH YDS / 4 RUSH TD / 98 RUSH YPG
Trequan Jones	RB	264 YDS / 4 TD / 132 YPG / 14.7 YPC
Na'eem Abdul-Rahim Gladding	WR	10 REC / 140 YDS / 2 TD / 46.7 YPG
Ja'Cory Thomas	WR	11 REC / 193 YDS / 1 TD / 64.3 YPG
Jeremy Mack Jr.	LB	5 TKL / 2 TFL / 2 SACK
Javen Gibson	DL	3 TKL / 0 TFL / 1.5 SACK
Jerome Carter	DB	5 TKL / 0 TFL / 2 INT / 2 PD
Nickendre Stiger	DB	6 TKL / 1 TFL

Liberty 2025 Key Players

Name	Position	Stats
Ethan Vasko	QB	763 YDS (57.3%) / 6 TD / 3 INT 142 RUSH YDS / 2 RUSH TD / 35.5 RUSH YPG
Evan Dickens	RB	311 YDS / 2 TD / 77.8 YPG / 5.7 YPC 4 REC / 59 REC YDS / 1 REC TD / 14.8 REC YPG
Donte Lee Jr.	WR	9 REC / 208 YDS / 3 TD / 52 YPG
Julian Gray	RB	72 YDS / 0 TD / 18 YPG / 6 YPC 8 REC / 94 REC YDS / 1 REC TD / 23.5 REC YPG
CJ Bazile Jr.	DL	10 TKL / 1 TFL / 1.5 SACK
Brylan Green	DB	8 TKL / 1 TFL / 1 INT / 1 PD
Derrell Farrar	LB	8 TKL / 1 TFL / 1 SACK
Brenton Williams	DL	8 TKL / 1 TFL / 1 SACK