Oklahoma vs. South Carolina Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 9:04 a.m. ET

Data Skrive

The No. 14 Oklahoma Sooners (5-1) are 4.5-point favorites when they visit the South Carolina Gamecocks (3-3) in an SEC matchup on Saturday, October 18, 2025 at Williams-Brice Stadium. The contest has a point total set at 42.5.

Facing the Texas Longhorns in their most recent contest, the Sooners lost 23-6. The Gamecocks lost to the LSU Tigers, 20-10, in their most recent game.

Keep up with college football all season on FOX Sports.

Oklahoma vs. South Carolina Game Information & Odds

When: Saturday, October 18, 2025 at 12:45 p.m. ET
Location: Williams-Brice Stadium in Columbia, South Carolina
TV: SEC Network
Live Box Score on FOX Sports

Oklahoma vs South Carolina Betting Information updated as of October 18, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oklahoma	-4.5 (-105)	-193	+160	42.5	-112	-108

Oklahoma vs. South Carolina Prediction

Pick ATS: Oklahoma (-4.5)
Pick OU: Under (42.5)
Prediction: Oklahoma 24, South Carolina 16

Predictions are made by the Data Skrive betting model.

Learn more about the Oklahoma Sooners vs. the South Carolina Gamecocks game on FOX Sports!

Oklahoma vs. South Carolina Betting Insights

Based on the spread and over/under, the implied score for the tilt is Sooners 24, Gamecocks 19.
The Sooners have a 65.9% chance to collect the win in this contest based on the moneyline's implied probability. The Gamecocks have a 38.5% implied probability.
Oklahoma has won three games against the spread this season, while failing to cover three times.
South Carolina has compiled a 3-3-0 ATS record so far this season.

Oklahoma vs. South Carolina: 2025 Stats Comparison

	Oklahoma	South Carolina
Off. Points per Game (Rank)	29.2 (68)	22.3 (107)
Def. Points per Game (Rank)	9.8 (2)	19 (29)
Turnovers Allowed (Rank)	9 (93)	6 (35)
Turnovers Forced (Rank)	2 (133)	12 (12)

Oklahoma 2025 Key Players

Name	Position	Stats
John Mateer	QB	1,417 YDS (64.2%) / 6 TD / 6 INT 195 RUSH YDS / 5 RUSH TD / 39 RUSH YPG
Isaiah Sategna	WR	30 REC / 420 YDS / 3 TD / 70 YPG
Tory Blaylock	RB	292 YDS / 3 TD / 48.7 YPG / 4.3 YPC
Deion Burks	WR	30 REC / 339 YDS / 2 TD / 56.5 YPG
Taylor Wein	DL	15 TKL / 8 TFL / 3.5 SACK
R Mason Thomas	DL	14 TKL / 3 TFL / 4 SACK
David Stone	DL	17 TKL / 3 TFL / 1.5 SACK
Jayden Jackson	DL	12 TKL / 2 TFL / 3 SACK

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	1,010 YDS (64%) / 4 TD / 2 INT 117 RUSH YDS / 1 RUSH TD / 19.5 RUSH YPG
Vandrevius Jacobs	WR	20 REC / 341 YDS / 2 TD / 68.2 YPG
Rahsul Faison	RB	231 YDS / 3 TD / 38.5 YPG / 4.3 YPC
Nyck Harbor	WR	13 REC / 256 YDS / 1 TD / 42.7 YPG
Dylan Stewart	DL	26 TKL / 8 TFL / 4 SACK
Bryan Thomas Jr.	DL	19 TKL / 4 TFL / 3 SACK
Fred Johnson	LB	25 TKL / 1 TFL / 1 SACK / 1 INT
DQ Smith	DB	29 TKL / 0 TFL / 1 INT / 1 PD