Oklahoma vs. Ole Miss Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 9:04 a.m. ET

Data Skrive

The No. 13 Oklahoma Sooners (6-1) will put their fourth-ranked pass defense to the test against the No. 8 Ole Miss Rebels (6-1) and the No. 9 pass offense in the country, on Saturday, October 25, 2025. The Sooners are favored by 5.5 points in the outing. The over/under for the game is set at 52.5.

The Sooners won versus the South Carolina Gamecocks in their last game, 26-7. In their most recent game, the Rebels lost versus the Georgia Bulldogs, 43-35.

Keep up with college football all season on FOX Sports.

Can Oklahoma upset Ole Miss? 🤔😲 Joel Klatt Show

Joel Klatt broke down the Ole Miss Rebels travelling to Norman to take on the Oklahoma Sooners. He analyzed if Oklahoma could potentially upset Ole Miss. Joel questioned if Oklahoma's offense can compete and if Ole Miss's defense will be stronger this weekend.

Oklahoma vs. Ole Miss Game Information & Odds

When: Saturday, October 25, 2025 at 12 p.m. ET
Location: Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma
TV: ABC
Live Box Score on FOX Sports

Oklahoma vs Ole Miss Betting Information updated as of October 25, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oklahoma	-5.5 (-110)	-202	+168	52.5	-109	-111

Oklahoma vs. Ole Miss Prediction

Pick ATS: Oklahoma (-5.5)
Pick OU: Under (52.5)
Prediction: Oklahoma 27, Ole Miss 22

Predictions are made by the Data Skrive betting model.

Learn more about the Oklahoma Sooners vs. the Ole Miss Rebels game on FOX Sports!

Oklahoma vs. Ole Miss Betting Insights

Based on the spread and over/under, the implied score for the game is Sooners 29, Rebels 24.
The Sooners have a 66.9% chance to collect the win in this game based on the moneyline's implied probability. The Rebels hold a 37.3% implied probability.
Oklahoma has won four games against the spread this season, while failing to cover three times.
Ole Miss has covered four times in seven chances against the spread this year.

Oklahoma vs. Ole Miss: 2025 Stats Comparison

	Oklahoma	Ole Miss
Off. Points per Game (Rank)	28.7 (70)	37.4 (17)
Def. Points per Game (Rank)	9.4 (2)	22.6 (53)
Turnovers Allowed (Rank)	9 (80)	8 (56)
Turnovers Forced (Rank)	4 (126)	4 (126)

Oklahoma 2025 Key Players

Name	Position	Stats
John Mateer	QB	1,567 YDS (64.9%) / 7 TD / 6 INT 209 RUSH YDS / 5 RUSH TD / 34.8 RUSH YPG
Isaiah Sategna	WR	37 REC / 493 YDS / 4 TD / 70.4 YPG
Tory Blaylock	RB	393 YDS / 4 TD / 56.1 YPG / 4.5 YPC
Deion Burks	WR	32 REC / 358 YDS / 2 TD / 51.1 YPG
Taylor Wein	DL	19 TKL / 10 TFL / 3.5 SACK / 1 INT
R Mason Thomas	DL	18 TKL / 4 TFL / 5.5 SACK
Jayden Jackson	DL	15 TKL / 2 TFL / 3 SACK
David Stone	DL	18 TKL / 3 TFL / 1.5 SACK

Ole Miss 2025 Key Players

Name	Position	Stats
Trinidad Chambliss	QB	1,549 YDS (62.7%) / 8 TD / 1 INT 323 RUSH YDS / 5 RUSH TD / 46.1 RUSH YPG
Kewan Lacy	RB	618 YDS / 10 TD / 88.3 YPG / 4.5 YPC 16 REC / 97 REC YDS / 0 REC TD / 16.2 REC YPG
Dae'Quan Wright	TE	19 REC / 393 YDS / 3 TD / 56.1 YPG
Deuce Alexander	WR	22 REC / 382 YDS / 1 TD / 54.6 YPG
Zxavian Harris	DL	29 TKL / 6 TFL / 3 SACK / 1 INT
William Echoles	DL	28 TKL / 4 TFL / 3 SACK
T.J. Dudley	LB	41 TKL / 1 TFL
Wydett Williams Jr.	DB	30 TKL / 0 TFL / 1 INT / 1 PD