Notre Dame vs. USC Prediction, Odds, Picks - October 18, 2025

Updated Oct. 18, 2025 3:04 p.m. ET

Data Skrive

Two of the nation's top offenses square off when the No. 13 Notre Dame Fighting Irish (4-2) take college football's 13th-ranked scoring offense into a matchup with the No. 20 USC Trojans (5-1), who have the No. 3 scoring offense, on Saturday, October 18, 2025. The Fighting Irish are massive, 10.5-point favorites. An over/under of 59.5 is set in the contest.

The Fighting Irish beat the North Carolina State Wolfpack, 36-7, in their most recent game. In their most recent contest, the Trojans won against the Michigan Wolverines, 31-13.

Keep up with college football all season on FOX Sports.

Notre Dame vs. USC Game Information & Odds

When: Saturday, October 18, 2025 at 7:30 p.m. ET
Location: Notre Dame Stadium in South Bend, Indiana
TV: NBC
Live Box Score on FOX Sports

Notre Dame vs USC Betting Information updated as of October 18, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-10.5 (-109)	-383	+301	59.5	-112	-108

Notre Dame vs. USC Prediction

Pick ATS: Notre Dame (-10.5)
Pick OU: Over (59.5)
Prediction: Notre Dame 39, USC 25

Predictions are made by the Data Skrive betting model.

Learn more about the Notre Dame Fighting Irish vs. the USC Trojans game on FOX Sports!

Notre Dame vs. USC Betting Insights

Per the spread and over/under, the implied score for the game is Fighting Irish 35, Trojans 24.
The Fighting Irish have a 79.3% chance to collect the win in this meeting based on the moneyline's implied probability. The Trojans have a 24.9% implied probability.
Notre Dame has compiled a 3-3-0 ATS record so far this year.
USC has put together a 3-3-0 record against the spread this season.

Notre Dame vs. USC: Head-to-Head

Over their last four meetings, Notre Dame has tallied three wins versus USC.
In those matchups versus USC, the Fighting Irish have covered three times while outpacing the total on three occasions.
In their last four head-to-head matchups, Notre Dame has racked up 155 points versus USC, while surrendering only 109 points.

Notre Dame vs. USC: 2025 Stats Comparison

	Notre Dame	USC
Off. Points per Game (Rank)	40 (14)	45.5 (3)
Def. Points per Game (Rank)	20.8 (44)	21.3 (47)
Turnovers Allowed (Rank)	6 (35)	7 (56)
Turnovers Forced (Rank)	12 (12)	11 (19)

Notre Dame 2025 Key Players

Name	Position	Stats
Jeremiyah Love	RB	530 YDS / 8 TD / 88.3 YPG / 5.3 YPC 14 REC / 160 REC YDS / 3 REC TD / 32 REC YPG
CJ Carr	QB	1,622 YDS (66.5%) / 13 TD / 3 INT 16 RUSH YDS / 1 RUSH TD / 2.7 RUSH YPG
Jadarian Price	RB	422 YDS / 7 TD / 70.3 YPG / 6.7 YPC 1 REC / 35 REC YDS / 1 REC TD / 17.5 REC YPG
Jordan Faison	WR	29 REC / 376 YDS / 2 TD / 62.7 YPG
Boubacar Traore	DL	23 TKL / 5 TFL / 4.5 SACK
Leonard Moore	DB	12 TKL / 0 TFL / 3 INT / 3 PD
Kyngstonn Viliamu-Asa	LB	25 TKL / 1 TFL / 0.5 SACK / 1 INT
Jalen Stroman	DB	22 TKL / 1 TFL / 1 SACK

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	1,852 YDS (71.9%) / 13 TD / 2 INT 50 RUSH YDS / 4 RUSH TD / 8.3 RUSH YPG
Makai Lemon	WR	44 REC / 682 YDS / 6 TD / 113.7 YPG
Waymond Jordan	RB	576 YDS / 5 TD / 96 YPG / 6.5 YPC
Eli Sanders	RB	264 YDS / 2 TD / 52.8 YPG / 5.6 YPC 8 REC / 126 REC YDS / 1 REC TD / 21 REC YPG
Eric Gentry	LB	23 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	14 TKL / 1 TFL / 1 SACK / 5 INT
Devan Thompkins	DL	11 TKL / 1 TFL / 3 SACK
Braylan Shelby	DL	6 TKL / 3 TFL / 3.5 SACK