Notre Dame vs. Purdue Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

The Purdue Boilermakers (2-1) are massive 24.5-point underdogs on Saturday, September 20, 2025 against the No. 24 Notre Dame Fighting Irish (0-2). The over/under is set at 51.5 points for the game.

Against the Texas A&M Aggies in their last game, the Fighting Irish lost 41-40. Against the USC Trojans in their last contest, the Boilermakers lost 33-17.

Keep up with college football all season on FOX Sports.

Notre Dame vs. Purdue Game Information & Odds

When: Saturday, September 20, 2025 at 3:30 p.m. ET
Location: Notre Dame Stadium in South Bend, Indiana
TV: NBC
Live Box Score on FOX Sports

Notre Dame vs Purdue Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-24.5 (-112)	-3030	+1276	51.5	-107	-113

Notre Dame vs. Purdue Prediction

Pick ATS: Purdue (+24.5)
Pick OU: Over (51.5)
Prediction: Notre Dame 38, Purdue 16

Predictions are made by the Data Skrive betting model.

Learn more about the Notre Dame Fighting Irish vs. the Purdue Boilermakers game on FOX Sports!

Notre Dame vs. Purdue Betting Insights

Based on the spread and over/under, the implied score for the game is Fighting Irish 38, Boilermakers 14.
The Fighting Irish have a 96.8% chance to collect the win in this contest based on the moneyline's implied probability. The Boilermakers have a 7.3% implied probability.
Notre Dame is winless against the spread this season (0-2-0).
Purdue has covered twice in three chances against the spread this year.

Notre Dame vs. Purdue: Head-to-Head

In their past two head-to-head bouts, Notre Dame has defeated Purdue two times.
In those matchups against Purdue, the Fighting Irish have covered two times while outpacing the point total on one occasion.
Over their last two head-to-head matchups, Notre Dame has scored 93 points, while Purdue has accumulated 20.

Notre Dame vs. Purdue: 2025 Stats Comparison

	Notre Dame	Purdue
Off. Points per Game (Rank)	32 (100)	27.3 (77)
Def. Points per Game (Rank)	34 (76)	16.7 (44)
Turnovers Allowed (Rank)	3 (53)	4 (78)
Turnovers Forced (Rank)	1 (120)	0 (130)

Notre Dame 2025 Key Players

Name	Position	Stats
CJ Carr	QB	514 YDS (62.9%) / 3 TD / 2 INT 1 RUSH YDS / 1 RUSH TD / 0.5 RUSH YPG
Jeremiyah Love	RB	127 YDS / 1 TD / 63.5 YPG / 3.8 YPC 8 REC / 79 REC YDS / 1 REC TD / 39.5 REC YPG
Jadarian Price	RB	113 YDS / 2 TD / 56.5 YPG / 6.3 YPC
Eli Raridon	TE	9 REC / 182 YDS / 0 TD / 91 YPG
Boubacar Traore	DL	6 TKL / 1 TFL / 1 SACK
Jalen Stroman	DB	9 TKL / 0 TFL
Leonard Moore	DB	3 TKL / 0 TFL / 1 INT / 1 PD
Drayk Bowen	LB	8 TKL / 0 TFL

Purdue 2025 Key Players

Name	Position	Stats
Ryan Browne	QB	786 YDS (63.6%) / 5 TD / 4 INT 59 RUSH YDS / 2 RUSH TD / 19.7 RUSH YPG
Devin Mockobee	RB	230 YDS / 3 TD / 76.7 YPG / 4 YPC 4 REC / 66 REC YDS / 0 REC TD / 22 REC YPG
Arhmad Branch	WR	7 REC / 167 YDS / 2 TD / 55.7 YPG
Nitro Tuggle	WR	8 REC / 130 YDS / 2 TD / 43.3 YPG
Charles Correa	LB	16 TKL / 3 TFL / 1 SACK
Mani Powell	LB	11 TKL / 2 TFL / 1 SACK
CJ Nunnally	DL	4 TKL / 2 TFL / 2 SACK
Myles Slusher	DB	12 TKL / 1 TFL