Notre Dame vs. Pittsburgh Prediction, Odds, Picks - October 28

Updated Oct. 28, 2023 3:05 p.m. ET

FOX Sports

The No. 14 Notre Dame Fighting Irish (6-2) are big 21-point favorites on Saturday, October 28, 2023 against the Pittsburgh Panthers (2-5). The total has been set at 45 points for this matchup.

The Fighting Irish beat the USC Trojans, 48-20, in their last game. Against the Wake Forest Demon Deacons in their last contest, the Panthers lost 21-17.

Notre Dame vs. Pittsburgh Game Information & Odds

When: Saturday, October 28, 2023 at 3:30 PM ET
Location: Notre Dame Stadium in South Bend, Indiana
TV: NBC
Live boxscore on FOX Sports

Notre Dame vs Pittsburgh Betting Information updated as of October 28, 2023, 2:46 PM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-21 (-110)	-1504	+843	45	-110	-110

Notre Dame vs. Pittsburgh Prediction

Pick ATS: Notre Dame (-21)
Pick OU: Over (45)
Prediction: Notre Dame 38, Pittsburgh 12

Learn more about the Notre Dame Fighting Irish vs. the Pittsburgh Panthers game on FOX Sports!

Notre Dame vs. Pittsburgh Betting Insights

Per the spread and over/under, the implied score for the game is Fighting Irish 33, Panthers 12.
The Fighting Irish have a 93.8% chance to collect the win in this contest based on the moneyline's implied probability. The Panthers hold a 10.6% implied probability.
Notre Dame is 5-2-1 ATS this season.
Pittsburgh has a record of 2-5-0 against the spread this year.

Notre Dame vs. Pittsburgh: 2023 Stats Comparison

	Notre Dame	Pittsburgh
Off. Points per Game (Rank)	35.9 (8)	24.6 (99)
Def. Points per Game (Rank)	16.4 (21)	24.6 (56)
Turnovers Allowed (Rank)	7 (25)	7 (25)
Turnovers Forced (Rank)	13 (20)	9 (78)

Notre Dame 2023 Key Players

Name	Position	Stats
Sam Hartman	QB	1,838 YDS (64.5%) / 18 TD / 3 INT 14 RUSH YDS / 2 RUSH TD / 1.8 RUSH YPG
Audric Estime	RB	787 YDS / 9 TD / 98.4 YPG / 6.2 YPC 11 REC / 93 REC YDS / 0 REC TD / 11.6 REC YPG
Chris Tyree	WR	16 REC / 355 YDS / 3 TD / 44.4 YPG
Mitchell Evans	TE	24 REC / 356 YDS / 1 TD / 44.5 YPG
Xavier Watts	S	35 TKL / 1.0 TFL / 4 INT / 5 PD
JD Bertrand	LB	51 TKL / 4.0 TFL / 1.5 SACK
Howard Cross III	DL	43 TKL / 3.0 TFL / 1.0 SACK
Marist Liufau	LB	33 TKL / 2.0 TFL / 1.5 SACK

Pittsburgh 2023 Key Players

Name	Position	Stats
Phil Jurkovec	QB	818 YDS (50.9%) / 6 TD / 3 INT 59 RUSH YDS / 1 RUSH TD / 8.4 RUSH YPG
C'Bo Flemister	RB	282 YDS / 2 TD / 40.3 YPG / 4.1 YPC 5 REC / 92 REC YDS / 1 REC TD / 13.1 REC YPG
Konata Mumpfield	WR	30 REC / 347 YDS / 3 TD / 49.6 YPG
Jerrod Means	WR	20 REC / 326 YDS / 3 TD / 46.6 YPG
Shayne Simon	LB	25 TKL / 4.0 TFL / 3.0 SACK
Solomon DeShields	LB	23 TKL / 6.0 TFL / 2.0 SACK
Bam Brima	DL	12 TKL / 3.0 TFL / 3.0 SACK
A.J. Woods	DB	17 TKL / 3.0 TFL / 2.0 SACK / 1 INT