Michigan vs. Purdue Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

FOX Sports

Oddsmakers heavily favor the No. 21 Michigan Wolverines (6-2) when they host the Purdue Boilermakers (2-6) on Saturday, November 1, 2025 in a matchup between Big Ten foes at Michigan Stadium. Michigan is favored by 21 points. A total of 48.5 points has been set for this matchup.

In their most recent action, the Wolverines won against the Michigan State Spartans, 31-20. Last time around, the Boilermakers fell to the Rutgers Scarlet Knights, with 27-24 being the final score.

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Michigan vs. Purdue Game Information & Odds

When: Saturday, November 1, 2025 at 7 p.m. ET
Location: Michigan Stadium in Ann Arbor, Michigan
TV: BTN
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Michigan vs Purdue Betting Information updated as of November 1, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Michigan	-21 (-110)	-1852	+1000	48.5	-112	-108

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Michigan vs. Purdue Prediction

Pick ATS: Michigan (-21)
Pick OU: Push
Prediction: Michigan 36, Purdue 13

Predictions are made by the Data Skrive betting model.

Learn more about the Michigan Wolverines vs. the Purdue Boilermakers game on FOX Sports!

Michigan vs. Purdue Betting Insights

Per the spread and over/under, the implied score for the tilt is Wolverines 35, Boilermakers 14.
The Wolverines have a 94.9% chance to claim victory in this meeting per the moneyline's implied probability. The Boilermakers hold a 9.1% implied probability.
Michigan has put together a 3-5-0 record against the spread this season.
Purdue has covered three times in eight games with a spread this year.

Michigan vs. Purdue: Head-to-Head

In their past two head-to-head meetings, Michigan has defeated Purdue two times.
In their last two matchups, each team has covered one time while both contests eclipsed the total.
Purdue has been outpaced by 49 points in its last two tilts against Michigan.

Michigan vs. Purdue: 2025 Stats Comparison

	Michigan	Purdue
Off. Points per Game (Rank)	29 (60)	22.9 (98)
Def. Points per Game (Rank)	17.4 (22)	27.8 (96)
Turnovers Allowed (Rank)	6 (13)	16 (127)
Turnovers Forced (Rank)	15 (13)	5 (123)

Michigan 2025 Key Players

Name	Position	Stats
Justice Haynes	RB	857 YDS / 10 TD / 122.4 YPG / 7.1 YPC
Bryce Underwood	QB	1,526 YDS (61.1%) / 7 TD / 2 INT 228 RUSH YDS / 4 RUSH TD / 28.5 RUSH YPG
Jordan Marshall	RB	544 YDS / 5 TD / 68 YPG / 5.5 YPC 6 REC / 49 REC YDS / 0 REC TD / 12.3 REC YPG
Andrew Marsh	WR	21 REC / 351 YDS / 2 TD / 58.5 YPG
Jimmy Rolder	LB	42 TKL / 4 TFL / 2 SACK / 1 INT
Derrick Moore	DL	18 TKL / 5 TFL / 6.5 SACK
Cole Sullivan	LB	19 TKL / 4 TFL / 2 SACK / 3 INT
Ernest Hausmann	LB	35 TKL / 3 TFL / 1 SACK

Purdue 2025 Key Players

Name	Position	Stats
Ryan Browne	QB	1,689 YDS (59.5%) / 8 TD / 7 INT 175 RUSH YDS / 4 RUSH TD / 21.9 RUSH YPG
Devin Mockobee	RB	521 YDS / 4 TD / 65.1 YPG / 4.2 YPC 18 REC / 215 REC YDS / 1 REC TD / 26.9 REC YPG
Nitro Tuggle	WR	19 REC / 315 YDS / 4 TD / 39.4 YPG
Michael Jackson III	WR	44 REC / 398 YDS / 1 TD / 49.8 YPG
Mani Powell	LB	67 TKL / 4 TFL / 1.5 SACK
CJ Nunnally	DL	28 TKL / 6 TFL / 5 SACK
Charles Correa	LB	56 TKL / 3 TFL / 1.5 SACK
Myles Slusher	DB	41 TKL / 1 TFL / 1 SACK / 1 INT