Louisville vs. Toledo Prediction, Odds, Picks - December 23, 2025

The Louisville Cardinals play the Toledo Rockets in the Boca Raton Bowl as 8.5-point favorites on December 23, 2025 at 2 p.m. ET on ESPN. The contest's point total is 43.5.

The Cardinals' last game was against the Kentucky Wildcats, and they won by a score of 41-0. In their most recent contest, the Rockets won against the Central Michigan Chippewas, 21-3.

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Louisville vs. Toledo Game Information & Odds

• When: Tuesday, December 23, 2025 at 2 p.m. ET
• Location: Flagler Credit Union Stadium in Boca Raton, Florida
• TV: ESPN
• Streaming: FOX One + ESPN Bundle

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Louisville vs. Toledo Prediction

• Pick ATS: Toledo (+8.5)
  
• Pick OU: Over (43.5)
  
• Prediction: Louisville 25, Toledo 21

Predictions are made by the Data Skrive betting model.

Learn more about the Louisville Cardinals vs. the Toledo Rockets game on FOX Sports!

Louisville vs. Toledo Betting Insights

• Per the spread and over/under, the implied score for the game is Cardinals 26, Rockets 18.
• The Cardinals have a 77.5% chance to claim victory in this contest per the moneyline's implied probability. The Rockets hold a 26.7% implied probability.
• Louisville has covered four times in 12 games with a spread this season.
• Toledo is 9-3-0 ATS this year.

Louisville vs. Toledo: 2025 Stats Comparison

Louisville 2025 Key Players

Toledo 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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