James Madison vs. Washington State Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 9:04 a.m. ET

Data Skrive

Two of the nation's best pass defenses square off when the No. 21 James Madison Dukes (9-1) take college football's 14th-ranked pass defense into a matchup with the Washington State Cougars (5-5), who have the No. 15 passing defense, on Saturday, November 22, 2025. The Dukes are massive, 14-point favorites. The over/under is set at 43.5.

The Dukes beat the Appalachian State Mountaineers, 58-10, in their last game. In their most recent contest, the Cougars won against the Louisiana Tech Bulldogs, 28-3.

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James Madison vs. Washington State Game Information & Odds

When: Saturday, November 22, 2025 at 1 p.m. ET
Location: Bridgeforth Stadium/Zane Showker Field in Harrisonburg, Virginia
TV: ESPN+
Live Box Score on FOX Sports

James Madison vs Washington State Betting Information updated as of November 22, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
James Madison	-14 (-108)	-625	+456	43.5	-109	-111

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James Madison vs. Washington State Prediction

Pick ATS: Washington State (+14)
Pick OU: Over (43.5)
Prediction: James Madison 31, Washington State 17

Predictions are made by the Data Skrive betting model.

Learn more about the James Madison Dukes vs. the Washington State Cougars game on FOX Sports!

James Madison vs. Washington State Betting Insights

Based on the spread and over/under, the implied score for the matchup is Dukes 29, Cougars 15.
The Dukes have an 86.2% chance to win this game per the moneyline's implied probability. The Cougars hold an 18.0% implied probability.
James Madison has put together a 7-3-0 record against the spread this season.
Washington State has covered six times in 10 chances against the spread this year.

James Madison vs. Washington State: 2025 Stats Comparison

	James Madison	Washington State
Off. Points per Game (Rank)	37.1 (18)	20.7 (117)
Def. Points per Game (Rank)	16.2 (11)	21 (33)
Turnovers Allowed (Rank)	12 (54)	15 (92)
Turnovers Forced (Rank)	12 (72)	6 (129)

James Madison 2025 Key Players

Name	Position	Stats
Alonza Barnett III	QB	2,089 YDS (61.6%) / 16 TD / 5 INT 396 RUSH YDS / 12 RUSH TD / 39.6 RUSH YPG
Wayne Knight	RB	840 YDS / 7 TD / 84 YPG / 6.2 YPC 35 REC / 368 REC YDS / 1 REC TD / 36.8 REC YPG
Landon Ellis	WR	32 REC / 532 YDS / 5 TD / 53.2 YPG
Jordan Fuller	RB	415 YDS / 5 TD / 51.9 YPG / 5.1 YPC
Trent Hendrick	LB	39 TKL / 4 TFL / 3 SACK
Jacob Thomas	DB	31 TKL / 2 TFL / 2 SACK / 2 INT
Aiden Gobaira	DL	20 TKL / 7 TFL / 4 SACK
Sahir West	DL	17 TKL / 5 TFL / 3.5 SACK

Washington State 2025 Key Players

Name	Position	Stats
Zevi Eckhaus	QB	1,390 YDS (64%) / 10 TD / 8 INT 248 RUSH YDS / 6 RUSH TD / 31 RUSH YPG
Kirby Vorhees	RB	473 YDS / 4 TD / 47.3 YPG / 4.5 YPC 18 REC / 100 REC YDS / 0 REC TD / 11.1 REC YPG
Josh Meredith	WR	44 REC / 588 YDS / 3 TD / 58.8 YPG
Tony Freeman	WR	38 REC / 390 YDS / 2 TD / 39 YPG
Parker McKenna	LB	51 TKL / 2 TFL / 1 SACK / 1 INT
Caleb Francl	LB	47 TKL / 4 TFL / 2 SACK
Isaac Terrell	DL	15 TKL / 7 TFL / 5 SACK
Tucker Large	DB	48 TKL / 1 TFL