Houston vs. Oklahoma State Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 9:04 a.m. ET

FOX Sports

Oddsmakers heavily favor the Houston Cougars (4-1) when they visit the Oklahoma State Cowboys (1-4) on Saturday, October 11, 2025 in a matchup between Big 12 foes at Boone Pickens Stadium. Houston is favored by 14.5 points. The over/under is 48.5.

The Cougars' last contest was versus the Texas Tech Red Raiders, and they lost by a score of 35-11. The Cowboys lost to the Arizona Wildcats, 41-13, in their most recent contest.

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Houston vs. Oklahoma State Game Information & Odds

When: Saturday, October 11, 2025 at 12 p.m. ET
Location: Boone Pickens Stadium in Stillwater, Oklahoma
TV: TNT
Live Box Score on FOX Sports

Houston vs Oklahoma State Betting Information updated as of October 11, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Houston	-14.5 (-118)	-667	+475	48.5	-108	-113

Houston vs. Oklahoma State Prediction

Pick ATS: Houston (-14.5)
Pick OU: Over (48.5)
Prediction: Houston 38, Oklahoma State 15

Predictions are made by the Data Skrive betting model.

Learn more about the Houston Cougars vs. the Oklahoma State Cowboys game on FOX Sports!

Houston vs. Oklahoma State Betting Insights

Per the spread and over/under, the implied score for the matchup is Cougars 32, Cowboys 17.
The Cougars have an 87.0% chance to collect the win in this contest based on the moneyline's implied probability. The Cowboys have a 17.4% implied probability.
Houston has compiled a 3-2-0 ATS record so far this year.
Oklahoma State has covered just once in five matchups with a spread this season.

Houston vs. Oklahoma State: 2025 Stats Comparison

	Houston	Oklahoma State
Off. Points per Game (Rank)	27.2 (91)	16.4 (130)
Def. Points per Game (Rank)	17.6 (26)	36.2 (125)
Turnovers Allowed (Rank)	4 (18)	4 (18)
Turnovers Forced (Rank)	7 (55)	6 (70)

Houston 2025 Key Players

Name	Position	Stats
Conner Weigman	QB	910 YDS (59.3%) / 6 TD / 2 INT 151 RUSH YDS / 4 RUSH TD / 30.2 RUSH YPG
Dean Connors	RB	355 YDS / 3 TD / 71 YPG / 4.4 YPC 11 REC / 68 REC YDS / 0 REC TD / 13.6 REC YPG
Amare Thomas	WR	16 REC / 284 YDS / 2 TD / 56.8 YPG
Stephon Johnson Jr.	WR	10 REC / 261 YDS / 2 TD / 52.2 YPG
Corey Platt Jr.	LB	9 TKL / 2 TFL / 2.5 SACK
Latreveon McCutchin	LB	16 TKL / 1 TFL / 1 SACK
Marc Stampley II	DB	11 TKL / 1 TFL / 1 SACK / 1 INT
Will James	DB	10 TKL / 1 TFL / 1 INT / 1 PD

Oklahoma State 2025 Key Players

Name	Position	Stats
Zane Flores	QB	696 YDS (55%) / 0 TD / 3 INT 114 RUSH YDS / 1 RUSH TD / 22.8 RUSH YPG
Rodney Fields Jr.	RB	213 YDS / 0 TD / 53.3 YPG / 5.2 YPC 14 REC / 125 REC YDS / 0 REC TD / 41.7 REC YPG
Trent Howland	RB	107 YDS / 2 TD / 35.7 YPG / 4.1 YPC 2 REC / 14 REC YDS / 0 REC TD / 14 REC YPG
Gavin Freeman	WR	16 REC / 144 YDS / 1 TD / 28.8 YPG
Parker Robertson	DB	31 TKL / 3 TFL / 1 INT / 1 PD
Wendell Gregory	LB	16 TKL / 8 TFL / 3 SACK
Brandon Rawls	LB	35 TKL / 1 TFL / 1.5 SACK
Bryan McCoy	LB	37 TKL / 0 TFL