Florida State vs. Virginia Prediction, Odds, Picks - September 26, 2025

Updated Sep. 26, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers give the No. 8 Florida State Seminoles (3-0) the edge when they visit the Virginia Cavaliers (3-1) on Friday, September 26, 2025 in a matchup between ACC foes at Scott Stadium. Florida State is favored by a touchdown. The contest has an over/under of 60.5 points.

Facing the Kent State Golden Flashes in their last game, the Seminoles won 66-10. The Cavaliers' last game was against the Stanford Cardinal, and they won by a score of 48-20.

Keep up with college football all season on FOX Sports.

Florida State vs. Virginia Game Information & Odds

When: Friday, September 26, 2025 at 7 p.m. ET
Location: Scott Stadium in Charlottesville, Virginia
TV: ESPN
Live Box Score on FOX Sports

Florida State vs Virginia Betting Information updated as of September 26, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Florida State	-7 (-112)	-260	+212	60.5	-108	-112

Florida State vs. Virginia Prediction

Pick ATS: Virginia (+7)
Pick OU: Over (60.5)
Prediction: Virginia 33, Florida State 30

Predictions are made by the Data Skrive betting model.

Learn more about the Florida State Seminoles vs. the Virginia Cavaliers game on FOX Sports!

Florida State vs. Virginia Betting Insights

Based on the spread and over/under, the implied score for the game is Seminoles 34, Cavaliers 27.
The Seminoles have a 72.2% chance to collect the win in this contest per the moneyline's implied probability. The Cavaliers hold a 32.1% implied probability.
Florida State has put together a perfect 2-0-0 record against the spread this season.
Virginia has put together a 3-1-0 record against the spread this season.

Florida State vs. Virginia: 2025 Stats Comparison

	Florida State	Virginia
Off. Points per Game (Rank)	58 (11)	45.5 (9)
Def. Points per Game (Rank)	10 (7)	19.5 (56)
Turnovers Allowed (Rank)	3 (31)	2 (17)
Turnovers Forced (Rank)	3 (93)	2 (115)

Florida State 2025 Key Players

Name	Position	Stats
Thomas Castellanos	QB	594 YDS (71.1%) / 3 TD / 1 INT 139 RUSH YDS / 3 RUSH TD / 46.3 RUSH YPG
Gavin Sawchuk	RB	160 YDS / 5 TD / 53.3 YPG / 6.4 YPC 2 REC / 56 REC YDS / 1 REC TD / 28 REC YPG
Micahi Danzy	WR	4 REC / 126 YDS / 0 TD / 42 YPG
Samuel Singleton Jr.	RB	168 YDS / 3 TD / 84 YPG / 12 YPC
Earl Little II	DB	15 TKL / 0 TFL / 1 INT / 2 PD
Jeremiah Wilson	DB	6 TKL / 0 TFL / 2 INT / 2 PD
Elijah Herring	LB	7 TKL / 1 TFL / 1 SACK
Mandrell Desir	DL	7 TKL / 2 TFL / 1 SACK

Virginia 2025 Key Players

Name	Position	Stats
Chandler Morris	QB	1,050 YDS (70.8%) / 8 TD / 1 INT 132 RUSH YDS / 1 RUSH TD / 33 RUSH YPG
J'mari Taylor	RB	298 YDS / 6 TD / 74.5 YPG / 6.2 YPC 8 REC / 44 REC YDS / 0 REC TD / 11 REC YPG
Trell Harris	WR	18 REC / 321 YDS / 3 TD / 80.3 YPG
Harrison Waylee	RB	214 YDS / 4 TD / 71.3 YPG / 8.2 YPC
Daniel Rickert	DL	10 TKL / 2 TFL / 2.5 SACK
Ethan Minter	DB	13 TKL / 2 TFL / 1 INT / 1 PD
Landon Danley	LB	16 TKL / 1 TFL
Devin Neal	DB	13 TKL / 1 TFL / 0.5 SACK