Alabama vs. South Carolina Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 3:04 p.m. ET

Data Skrive

The No. 4 Alabama Crimson Tide (6-1) visit the South Carolina Gamecocks (3-4) on Saturday, October 25, 2025 in a matchup between SEC foes at Williams-Brice Stadium. South Carolina is an 11.5-point underdog. The game has a point total set at 48.

Facing the Tennessee Volunteers in their most recent contest, the Crimson Tide won 37-20. In their most recent game, the Gamecocks lost against the Oklahoma Sooners, 26-7.

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Alabama vs. South Carolina Game Information & Odds

When: Saturday, October 25, 2025 at 3:30 p.m. ET
Location: Williams-Brice Stadium in Columbia, South Carolina
TV: ABC
Live Box Score on FOX Sports

Alabama vs South Carolina Betting Information updated as of October 25, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Alabama	-11.5 (-111)	-463	+357	48	-110	-110

Alabama vs. South Carolina Prediction

Pick ATS: Alabama (-11.5)
Pick OU: Under (48)
Prediction: Alabama 31, South Carolina 15

Predictions are made by the Data Skrive betting model.

Learn more about the Alabama Crimson Tide vs. the South Carolina Gamecocks game on FOX Sports!

Alabama vs. South Carolina Betting Insights

Based on the spread and over/under, the implied score for the matchup is Crimson Tide 30, Gamecocks 18.
The Crimson Tide have an 82.2% chance to collect the win in this contest per the moneyline's implied probability. The Gamecocks have a 21.9% implied probability.
Alabama has covered five times in seven matchups with a spread this season.
South Carolina has compiled a 3-4-0 record against the spread this year.

Alabama vs. South Carolina: 2025 Stats Comparison

	Alabama	South Carolina
Off. Points per Game (Rank)	35.1 (32)	20.1 (116)
Def. Points per Game (Rank)	17.7 (22)	20 (36)
Turnovers Allowed (Rank)	3 (4)	8 (56)
Turnovers Forced (Rank)	12 (22)	12 (22)

Alabama 2025 Key Players

Name	Position	Stats
Ty Simpson	QB	1,931 YDS (70.2%) / 18 TD / 1 INT 66 RUSH YDS / 2 RUSH TD / 9.4 RUSH YPG
Germie Bernard	WR	33 REC / 472 YDS / 5 TD / 67.4 YPG
Ryan Williams	WR	26 REC / 423 YDS / 3 TD / 70.5 YPG
Isaiah Horton	WR	22 REC / 272 YDS / 5 TD / 38.9 YPG
Yhonzae Pierre	LB	24 TKL / 6 TFL / 4 SACK
Justin Jefferson	LB	40 TKL / 1 TFL / 1 SACK / 1 INT
Bray Hubbard	DB	31 TKL / 1 TFL / 3 INT / 3 PD
Lebbeus Thomas Overton	DL	22 TKL / 3 TFL / 3 SACK

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	1,134 YDS (64.7%) / 5 TD / 2 INT 108 RUSH YDS / 1 RUSH TD / 15.4 RUSH YPG
Rahsul Faison	RB	281 YDS / 3 TD / 40.1 YPG / 4.4 YPC
Vandrevius Jacobs	WR	21 REC / 343 YDS / 2 TD / 57.2 YPG
Nyck Harbor	WR	17 REC / 278 YDS / 2 TD / 39.7 YPG
Dylan Stewart	DL	26 TKL / 8 TFL / 4 SACK
Bryan Thomas Jr.	DL	21 TKL / 5 TFL / 4 SACK
Fred Johnson	LB	30 TKL / 2 TFL / 1 SACK / 1 INT
DQ Smith	DB	35 TKL / 0 TFL / 1 INT / 1 PD