USC vs. Oregon Prediction, How to Watch, Odds, Channel - Feb 21

Updated Feb. 21, 2026 3:27 p.m. ET

FOX Sports

The Oregon Ducks (9-17, 2-13 Big Ten) will visit the USC Trojans (18-8, 7-8 Big Ten) after losing five straight road games. The matchup tips at 4 p.m. ET on Saturday, February 21, 2026.

The Trojans are a 5.5-point favorite against the Ducks when the Trojans and the Ducks square off. The matchup's over/under is set at 147.5.

Continue scrolling to get all you need to know ahead of placing bets on the USC-Oregon matchup.

USC vs. Oregon How to Watch & Odds

When: Saturday, February 21, 2026 at 4 p.m. ET
Where: Galen Center in Los Angeles, California
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Trojans vs Ducks Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Trojans	-5.5	-110	-113	147.5	-111	-111	-249	+200

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USC vs. Oregon Prediction

Pick ATS: USC (-5.5)
Pick OU: Over (147.5)
Prediction: USC 80, Oregon 72

Learn more about the USC Trojans vs. the Oregon Ducks game on FOX Sports!

USC vs. Oregon Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the matchup is Trojans 76, Ducks 71.
The Trojans have a 71.3% chance to win this meeting based on the moneyline's implied probability.
The Ducks hold a 33.3% implied probability to come out on top.

Key Spread Facts

USC is 13-12-0 ATS this season.
Oregon has won eight games against the spread this season, while failing to cover 18 times.
USC has covered the spread six times this season (6-7 ATS) when playing as at least 5.5-point favorites.
Oregon is 3-6 ATS this season when playing as at least 5.5-point underdogs.

Key Total Facts

A total of 17 times so far this year, the Trojans and their opponent have combined for more than 147.5 points.
So far this season, 13 Ducks games have featured more than 147.5 points scored.
The Trojans and Ducks average 151.9 points per game combined, which is 4.4 more than the over/under for this matchup.

Key Moneyline Facts

USC has won 87.5% of its games this season when favored on the moneyline (14-2).
This season, Oregon has been listed as the underdog in 13 games and failed to win any of those contests.
When it has played as a moneyline favorite with odds of -249 or shorter, USC has gone 11-1 (91.7% win percentage).
Oregon has not won as an underdog of +200 or more on the moneyline this season in nine games with those odds or longer.

USC vs. Oregon: Recent Results

Trojans vs Ducks Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
12/2/2025	Trojans	-2.5	154.5	-151	+127	82-77 USC
3/1/2025	Ducks	-6.5	152	-319	+255	82-61 ORE
12/4/2024	Ducks	-5.5	148	-253	+205	68-60 ORE

USC vs. Oregon: 2025-26 Stats Comparison

	USC	Oregon
Points Scored Per Game (Rank)	80.7 (84)	71.2 (291)
Points Allowed (Rank)	76.8 (258)	74.3 (197)
Rebounds (Rank)	9.8 (130)	10.2 (90)
3pt Made (Rank)	6.3 (311)	8.1 (153)
Assists (Rank)	15.3 (94)	14.1 (166)
Turnovers (Rank)	12.1 (282)	11.5 (224)

USC 2025-26 Key Players

Trojans Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Rodney Rice	6	20.3	3.3	6.0	1.2	0.2	2.5
Chad Baker-Mazara	23	18.3	4.2	3.0	0.7	1.3	2.2
Ezra Ausar	26	15.7	6.2	1.8	1.0	0.4	0.0
Alijah Arenas	8	14.5	2.6	1.5	1.0	0.5	1.1
Jacob Cofie	26	10.1	7.1	2.0	1.0	1.6	0.6

Oregon 2025-26 Key Players

Ducks Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Nathan Bittle	19	16.8	6.7	2.5	0.6	2.1	1.5
Jackson Shelstad	12	15.6	2.9	4.9	1.4	0.1	2.8
Kwame Evans Jr.	24	12.5	7.2	2.2	1.0	1.3	1.0
TK Simpkins	25	12.4	2.9	2.1	1.0	0.2	1.8
Sean Stewart	26	7.0	5.4	1.0	0.9	0.5	0.0