Duke vs. Houston Prediction, Odds, Picks - NCAA Tournament Final Four

Updated Apr. 5, 2025 8:27 p.m. ET

Data Skrive

The No. 1 seed Duke Blue Devils (35-3) and No. 1 seed Houston Cougars (34-4) will both look to claim a place in the NCAA Tournament national championship game when they square off in the Final Four on Saturday at Alamodome, beginning at 8:49 p.m. ET, airing on CBS.

The Blue Devils are a 4.5-point favorite against the Cougars when the Blue Devils and the Cougars meet. The over/under for the matchup is 136.5.

Keep scrolling to get the download ahead of wagering on the Duke-Houston contest.

Duke vs. Houston Game Information & Odds

When: Saturday, April 5, 2025 at 8:49 p.m. ET
Where: Alamodome in San Antonio, Texas
How to watch on TV: CBS
Live boxscore on FOX Sports

Blue Devils vs Cougars Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Blue Devils	-4.5	-108	-112	136.5	-108	-112	-245	+200

Duke vs. Houston Prediction

Pick ATS: Houston (+4.5)
Pick OU: Over (136.5)
Prediction: Duke 71, Houston 68

Learn more about the Duke Blue Devils vs. the Houston Cougars game on FOX Sports!

Duke vs. Houston Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the encounter is Blue Devils 70, Cougars 66.
The Blue Devils have a 71.0% chance to win this matchup per the moneyline's implied probability.
The Cougars sit with a 33.3% implied probability to win.

Key Spread Facts

Duke has compiled a 24-13-0 record against the spread this season.
Houston has covered 20 times in 37 games with a spread this year.
Duke is 22-12 ATS this season when playing as at least 4.5-point favorites.

Key Total Facts

The Blue Devils games have had more than 136.5 points scored on 28 occasions this year.
There have been 14 Cougars games this year with more than 136.5 points scored.
The Blue Devils and Cougars combine to average 157.7 points per contest, which is 21.2 more than the total for this game.

Key Moneyline Facts

Duke has put together a 32-3 record in games when it was listed as the moneyline favorite (winning 91.4% of those games).
Houston won the only game it has played as the underdog this season.
When playing as a moneyline favorite with odds of -245 or shorter, Duke has gone 31-1 (96.9% win percentage).
Houston has not entered a game this season with longer moneyline odds than +200.

Duke vs. Houston: Recent Results

Blue Devils vs Cougars Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
3/29/2024	Cougars	-4.5	133.5	-218	+180	54-51 DUKE

Duke vs. Houston: 2024-25 Stats Comparison

	Duke	Houston
Points Scored Per Game (Rank)	83.7 (9)	74 (167)
Points Allowed (Rank)	62.6 (7)	58.3 (1)
Rebounds (Rank)	9.5 (127)	10.9 (37)
3pt Made (Rank)	10.2 (21)	8.2 (121)
Assists (Rank)	17 (16)	12.3 (274)
Turnovers (Rank)	9 (9)	8.4 (3)

Duke 2024-25 Key Players

Blue Devils Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Cooper Flagg	36	18.9	7.5	4.2	1.4	1.3	1.4
Kon Knueppel	38	14.4	4	2.8	1.1	0.2	2.1
Tyrese Proctor	37	12.5	3.1	2.3	0.9	0.1	2.4
Khaman Maluach	38	8.7	6.7	0.5	0.2	1.3	0.1
Sion James	38	8.7	4.1	3	0.9	0.3	0.8

Houston 2024-25 Key Players

Cougars Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
LJ Cryer	38	15.4	2.3	2	0.9	0.1	3
Emanuel Sharp	35	12.7	3	0.9	1.4	0	2.4
Milos Uzan	38	11.6	3	4.3	0.9	0.1	1.6
J'wan Roberts	35	10.7	6.3	1.7	1	0.7	0
Terrance Arceneaux	38	6.8	2.7	0.8	0.9	0.3	0.7