DePaul vs. Buffalo Prediction, How to Watch, Odds, Channel - Nov 11

The Buffalo Bulls (2-0) battle the DePaul Blue Demons (2-0) at Wintrust Arena on Tuesday, November 11, 2025. The game tips at 8 p.m. ET on ESPN+.

The Blue Demons head into their game against the Bulls as heavy favorites. The Blue Demons are favored by 18.5 points. The matchup's point total is set at 153.5.

Keep reading to get the download ahead of wagering on the DePaul-Buffalo contest.

DePaul vs. Buffalo How to Watch & Odds

• When: Tuesday, November 11, 2025 at 8 p.m. ET
• Where: Wintrust Arena in Chicago, Illinois
• TV: ESPN+
• Live Box Score: FOX Sports

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DePaul vs. Buffalo Prediction

• Pick ATS: Buffalo (+18.5)
  
• Pick OU: Under (153.5)
  
• Prediction: DePaul 86, Buffalo 68

Learn more about the DePaul Blue Demons vs. the Buffalo Bulls game on FOX Sports!

DePaul vs. Buffalo Betting Insights

Betting Line Implied Predictions

• Per the spread and over/under, the implied score for the encounter is Blue Demons 86, Bulls 68.
• The Blue Demons have a 97.4% chance to win this meeting based on the moneyline's implied probability.
• The Bulls hold a 6.6% implied probability to come out on top.

Key Spread Facts

• DePaul went 17-17-0 ATS last season.
• Buffalo covered 12 times in 29 matchups with a spread last year.
• DePaul was favored by 18.5 points or more two times last season, and covered the spread in one of those matchups.
• Buffalo was an underdog by 18.5 points or more three times last year, and covered the spread in two of those games.

Key Total Facts

• The Blue Demons and their opponent broke the 153.5-point mark 12 times last season.
• Bulls games went over 153.5 points on 15 occasions last season.
• Last season, the two teams averaged a combined 144.2 points per contest, 9.3 fewer than the total for this matchup.

Key Moneyline Facts

• DePaul won 90.9% of the games last season in which it was favored on the moneyline (10-1).
• Last season, Buffalo was the underdog 27 times and won five, or 18.5%, of those games.
• DePaul never played as a moneyline favorite of -3704 or shorter.
• Buffalo did not win as an underdog of +1413 or more on the moneyline last season in three games with those odds or longer.

DePaul vs. Buffalo: 2024-25 Stats Comparison

DePaul 2024-25 Top Performers

Buffalo 2024-25 Top Performers

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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DePaul Blue Demons

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