Lookman has played 460 league minutes for Atletico Madrid this season and has scored one goal, remaining a regular starter for coach Diego Simeone, although the addition of Jonathan David could impact his playing time.
Romero has started the last four games across all competitions with his new club Atletico Madrid after building his fitness following his signature during the summer transfer window.
Seimen has returned to full team training after recovering from a hamstring injury and is expected to be available against Paderborn, according to ZVW.