Vikings vs. Bengals 2025 Prediction, Odds, Picks - Sep 21

The Minnesota Vikings (1-1) are considered favorites (-3) according to the oddsmakers ahead of their game versus the Cincinnati Bengals (2-0) on September 21, 2025, starting at 1 p.m. ET, airing on CBS. The expected point total for the game is 42.5.

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Vikings vs. Bengals Odds & Betting Lines

Vikings vs. Bengals Prediction & Pick

• Pick ATS: Vikings (-3)
  
• Pick OU: Over (42.5)
  
• Prediction: Vikings 30 - Bengals 19

How to Watch Minnesota vs. Cincinnati

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: U.S. Bank Stadium
• Location: Minneapolis, Minnesota
• TV: CBS
• Live Boxscore: FOX Sports

Vikings vs. Bengals Recent Matchups

• Cincinnati has a 2-1 record against Minnesota in their last three matchups.
• Cincinnati has been outscored by 21 points in its last three tilts against Minnesota.

Minnesota Betting Info

• This year, Minnesota has one win against the spread.
• The Vikings have not covered the spread this season (0-1 ATS) when playing as at least 3-point favorites.
• Minnesota games this year have gone over the total in one out of two opportunities (50%).
• The Vikings have been moneyline favorites in two other matchups this season, and they split them.
• The Vikings have a 61.8% chance to win this contest, based on the implied probability of the moneyline.

Vikings Stats

Minnesota's Key Players

Offense

• J.J. McCarthy has thrown for 301 yards, two touchdowns and three interceptions this year. He is averaging 150.5 yards per game and 7.3 per attempt, while completing 58.5% of his passes.
• He has also rushed for 50 yards (second on the Vikings) and added one touchdown on the ground, while averaging 25.0 rushing yards per game.
• Justin Jefferson's 125 receiving yards this season have come from 13 targets and seven receptions. He's averaging 62.5 receiving yards and 3.5 catches per game, with one receiving touchdown.
• Through two games, Jordan Mason has amassed 98 yards on the ground, averaging 49.0 yards per game without scoring a touchdown.
• Jalen Nailor has put up 59 receiving yards without a touchdown with four catches on eight targets. He's averaging 2.0 receptions and 29.5 yards per game.

Defense

• On the defensive side for the Vikings, Javon Hargrave has put up 10 tackles, 2.0 TFL, and two sacks in 2025.
• Theo Jackson has 13 tackles this season. His tackle total leads the Vikings.
• Ivan Pace has recorded 13 tackles and 1.0 TFL this year. He leads the Vikings in tackles.
• Jonathan Greenard has six tackles, 1.0 TFL, and one sack.

Cincinnati Betting Info

• Cincinnati has covered the spread in a matchup one time this season (1-1-0).
• Games involving Cincinnati have hit the over once this year.
• The Bengals will play as the underdog for the first time this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Bengals have a 42.4% chance to win.

Bengals Stats

Cincinnati's Key Players

Offense

• Ja'Marr Chase has registered 191 receiving yards (eighth in the NFL) and one touchdown on 16 receptions (fourth in the NFL), while being targeted 21 times this season.
• Jake Browning has 241 passing yards, two touchdowns and three interceptions. His completion percentage is 65.6% and he averages 241.0 yards per game and 7.5 per attempt.
• He has added 1 rushing yard (third on the Bengals), with one touchdown on the ground (averaging 1.0 yards per game and 1.0 per carry).
• Chase Brown is averaging 45.0 rushing yards per game this season (90 total yards), while scoring one rushing touchdown.
• In addition to his rushing stats, Brown has grabbed four passes (on six targets) for 26 yards (fifth on the Bengals). He averages 13.0 yards per game.
• Tee Higgins has 89 receiving yards and one touchdown from six receptions after getting 12 targets.

Defense

• Daxton Hill's 2025 showing includes 17 tackles, 1.0 TFL, and one interception in two games. He leads the Bengals in tackles.
• Trey Hendrickson has six tackles, 2.0 TFL, two sacks, and one pass defended.
• Jordan Battle has 16 tackles and two interceptions in the 2025 season. He is second on the Bengals in tackles.
• Logan Wilson has put up 15 tackles over two games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Minnesota Vikings

Cincinnati Bengals