The Biggest NFL Upsets in Week 6 - 2025

Looking for upsets? Multiple teams overcame the odds in Week 6 of the 2025 NFL season. Find out more about those underdogs who came out on top below.

Read more about last week's NFL games on FOX Sports!

NFL Week 6's Biggest Upsets

Giants 34, Eagles 17

• Spread: Eagles -7.5
• Total: Over (40.5)
• Moneyline: Eagles -400, Giants +310

Bears 25, Commanders 24

• Spread: Commanders -5.5
• Total: Under (49.5)
• Moneyline: Commanders -250, Bears +200

Falcons 24, Bills 14

• Spread: Bills -3.5
• Total: Under (49.5)
• Moneyline: Bills -210, Falcons +170

Panthers 30, Cowboys 27

• Spread: Cowboys -3
• Total: Over (47.5)
• Moneyline: Cowboys -160, Panthers +135

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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