Seahawks vs. Colts 2025 Prediction, Odds, Picks - Dec 14

The Seattle Seahawks (10-3) are big favorites (-13.5) over the Indianapolis Colts (8-5). The Colts have dropped three games in a row. The predicted point total for the game is 42.5.

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Seahawks vs. Colts Odds & Betting Lines

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Seahawks vs. Colts Prediction & Pick

• Pick ATS: Colts (+13.5)
  
• Pick OU: Over (42.5)
  
• Prediction: Seahawks 30 - Colts 19

How to Watch Seattle vs. Indianapolis

• Game date: Sunday, December 14, 2025
• Time: 4:25 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: CBS
• Live Boxscore: FOX Sports

Seahawks vs. Colts Recent Matchups

• Seattle owns a 2-0 record against Indianapolis in their last two matchups.
• Indianapolis has been outpaced by 40 points in its last two tilts against Seattle.

Seattle Betting Info

• Seattle is 10-3-0 against the spread this year.
• Seattle has combined with its opponent to hit the over in 61.5% of its contests this year (eight times over 13 games with a set point total).
• The Seahawks have put together a 9-1 record in games they played as the moneyline favorite (winning 90% of those games).
• The Seahawks have a 90.9% chance to win this contest, based on the implied probability of the moneyline.

Seahawks Stats

Seattle's Key Players

Offense

• Jaxon Smith-Njigba has brought in 89 passes (fourth in the NFL) on 121 targets for 1,428 total yards (first in the NFL) and nine touchdowns. He is averaging 6.8 catches and 109.8 yards per game through 13 games played.
• Sam Darnold has 3,162 passing yards (sixth in the NFL), 22 touchdowns (fifth in the NFL) and 11 interceptions this year. He has completed 68.1% of his passes, averaging 243.2 yards per game and 8.9 per attempt.
• Kenneth Walker III's output on the ground this season includes 762 yards and four TDs. He is averaging 58.6 yards per game and 4.5 per attempt (19th in the NFL).
• Walker has recorded 21 receptions, 174 yards and zero TDs through the air.
• In the running game, Zach Charbonnet averages 3.7 yards per attempt (38th in the NFL) and 40.3 yards per game for 483 total rushing yards. He has recorded eight rushing touchdowns this season.

Defense

• On the defensive side for the Seahawks, Ernest Jones has racked up 94 tackles, 3.0 TFL, 0.5 sacks, and five interceptions in 2025.
• Drake Thomas has 61 tackles, 10.0 TFL, 3.5 sacks, and six passes defended.
• Leonard Williams has put up 50 tackles, 7.0 TFL, seven sacks, and one pass defended.
• This season, Demarcus Lawrence has 33 tackles, 9.0 TFL, and five sacks.

Indianapolis Betting Info

• Indianapolis has put together a record of 7-6-0 against the spread this year.
• Games involving Indianapolis have hit the over on seven occasions this year.
• The Colts have entered the game as underdogs four times this season and won twice.
• The sportsbooks' moneyline implies a 13.3% chance of a victory for the Colts.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor has rushed for 16 touchdowns this year, and has accumulated 1,356 total rushing yards (104.3 per game and 5.5 per attempt).
• Taylor's offensive contributions include 35 receptions (2.7 per game) on 40 targets for 304 yards (23.4 per game) and two receiving touchdowns.
• Michael Pittman Jr. has put together a 2025 stat sheet that includes 69 catches for 699 yards and seven receiving touchdowns (seventh in the NFL) in 13 games played. He has been on the receiving end of 94 targets and is averaging 5.3 receptions per game.
• Through 13 games played this season, Tyler Warren has 60 catches (4.6 receptions per game on 6.5 targets per game) for 699 yards and four receiving touchdowns.
• Alec Pierce has 38 catches for 769 yards and two receiving touchdowns. He averages 3.5 yards per game through 11 games and has been targeted 67 times.

Defense

• In 2025, Germaine Pratt has amassed 5.0 TFL and 98 tackles through 12 games.
• Nick Cross has registered 2.5 sacks in addition to his 4.0 TFL, 88 tackles, and one interception through 13 games.
• During the 2025 season, Zaire Franklin has 94 tackles, 4.0 TFL, and two sacks through 13 games.
• Laiatu Latu's season stats include 35 tackles, 7.0 TFL, 5.5 sacks, and three interceptions through 12 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Seattle Seahawks

Indianapolis Colts