Seahawks vs. Colts 2025 Prediction, Odds, Picks - Dec 14

The Indianapolis Colts (8-5) will be attempting to end a three-game losing run against the Seattle Seahawks (10-3). The Seahawks are heavy favorites (-13.5). The expected point total for the matchup is set at 42.5.

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Seahawks vs. Colts Odds & Betting Lines

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Seahawks vs. Colts Prediction & Pick

• Pick ATS: Colts (+13.5)
  
• Pick OU: Over (42.5)
  
• Prediction: Seahawks 30 - Colts 19

How to Watch Seattle vs. Indianapolis

• Game date: Sunday, December 14, 2025
• Time: 4:25 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: CBS
• Live Boxscore: FOX Sports

Seahawks vs. Colts Recent Matchups

• In their past two head-to-head bouts, Seattle has defeated Indianapolis two times.
• Over their last two head-to-head contests, Seattle has scored 74 points, while Indianapolis has posted 34.

Seattle Betting Info

• Seattle has played 13 games, posting 10 wins against the spread.
• Seattle games in 2025 have gone over the point total eight times in 13 opportunities (61.5%).
• When playing as moneyline favorites, the Seahawks have won 90% of the time (9-1).
• Looking at this matchup's moneyline, the Seahawks' implied win probability is 92.3%.

Seahawks Stats

Seattle's Key Players

Offense

• Jaxon Smith-Njigba's 1,428 receiving yards this season (first in the NFL) have come from 89 receptions (fourth in the NFL) on 121 targets. He's averaging 6.8 catches and 109.8 yards per game, with nine receiving touchdowns (second in the NFL).
• Sam Darnold has 3,162 passing yards (sixth in the NFL), 22 touchdowns (fifth in the NFL) and 11 interceptions this year. He has completed 68.1% of his attempts, averaging 243.2 yards per game and 8.9 per attempt.
• In 13 games, Kenneth Walker III has picked up 762 rushing yards, averaging 58.6 yards per game and scoring four touchdowns.
• Walker has totaled 21 receptions on 26 targets for 174 yards, though he has not scored a touchdown in the passing game.
• Zach Charbonnet has run for 483 yards, averaging 40.3 yards per game and scoring eight touchdowns.

Defense

• On the defensive side for the Seahawks, Ernest Jones has powered the unit with 94 tackles, 3.0 TFL, 0.5 sacks, and five interceptions in 2025.
• Drake Thomas has 3.5 sacks (fifth on the Seahawks) as well as 10.0 TFL and 61 tackles.
• This season, Leonard Williams has recorded 7.0 sacks (first on the Seahawks) to go with 7.0 TFL and 50 tackles.
• This season, Demarcus Lawrence has 33 tackles, 9.0 TFL, and five sacks.

Indianapolis Betting Info

• Indianapolis has covered the spread seven times over 13 games with a set total.
• This year, seven Indianapolis games have gone over the point total.
• This season, the Colts have won two out of the four games in which they've been the underdog.
• The implied probability of a win by the Colts based on the moneyline is 11.8%.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor has rushed for 16 touchdowns this year, and has racked up 1,356 total rushing yards (104.3 per game and 5.5 per carry).
• Taylor's offensive contributions include 35 receptions (2.7 per game) on 40 targets for 304 yards (23.4 per game) and two receiving touchdowns.
• Michael Pittman Jr. has 69 catches for 699 yards and seven receiving touchdowns (seventh in the NFL). He has been targeted 94 times and averages 5.3 receptions per game through 13 games played.
• Through 13 games played this season, Tyler Warren has 60 catches (4.6 receptions per game on 6.5 targets per game) for 699 yards and four receiving touchdowns.
• Alec Pierce has been targeted 67 times, resulting in 38 catches for 769 yards .

Defense

• Germaine Pratt's 2025 output includes 98 tackles and 5.0 TFL in 12 games. He leads the Colts in tackles.
• Nick Cross has 88 tackles, 4.0 TFL, 2.5 sacks, and one interception. He is third on the Colts in tackles.
• Zaire Franklin has 2.0 sacks in addition to his 4.0 TFL and 94 tackles.
• Laiatu Latu has intercepted three passes in addition to 35 tackles, 7.0 TFL, 5.5 sacks, and four passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Seattle Seahawks

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